Table 4.

Percental change in laboratory and clinical parameters during ECAD in first treatment cycle.

	Total cohort	MARS	ADVOS	SPAD	OPAL	p-value
Bilirubin [%]-change	−18.0 [−27.18 to −4.97]	−5.0 [−18.16 to 0.00]	−18.5 [−26.43 to −2.49]	−14.3 [−24.21 to −9.14]	−29.1 [−37.97 to −21.62]	0.06
Ammonia [%]-change	−16.4 [−27.38 to 11.98]	10.0 [−22.56 to 32.63]	−17.5 [−30.69 to 2.95]	9.2 [−20.63 to 20.83]	−23.8 [−32.47 to 6.56]	0.172
Creatinine [%]-change	−21.1 [−34.96 to −6.09]	−10.3 [−26.68 to 11.97]	−21.6 [−33.94 to −10.36]	−10.4 [−29.66 to 0.18]	−34.4 [−47.64 to −14.71]	0.022
Urea [%]-change	−23.6 [−41.49 to −10.61]	−12.8 [−23.59 to 7.57]	−38.0 [−48.69 to −19.42]	−9.3 [−18.56 to −0.29]	−18.8 [−33.64 to −9.34]	0.001
Hemoglobin [%]-change	0.0 [−7.48 to 7.28]	−2.0 [−8.23 to 2.50]	−1.8 [−9.80 to 5.88]	7.1 [−2.37 to 13.33]	2.0 [−3.57 to 6.53]	0.108
Platelet count [%]-change	−20.5 [−40.50 to −2.12]	−32.5 [−39.63 to −2.74]	−25.5 [−48.19 to −2.86]	−9.1 [−36.36 to −3.62]	−9.7 [−31.02 to 13.95]	0.292
Fibrinogen [%]-change	−4.8 [−33.33 to 11.43]	−7.3 [−16.67 to 12.86]	−15.6 [−42.33 to 13.84]	0.0 [−31.41 to 8.75]	−8.9 [−25.35 to 9.92]	0.637
INR [%]-change	0.0 [−22.22 to 12.50]	0.0 [−14.29 to 21.15]	0.0 [−22.22 to 12.50]	−5.0 [−21.52 to 8.33]	−4.2 [−25.35 to 10.80]	0.91
Lactate [%]-change	2.6 [−23.49 to 37.65]	1.4 [−25.00 to 23.18]	0.0 [−27.66 to 38.10]	21.7 [−17.03 to 63.92]	−3.2 [−15.50 to 31.55]	0.595
pH [%]-change	0.4 [−0.20 to 0.96]	0.3 [−0.34 to 0.85]	0.5 [0.00–1.33]	0.4 [−0.40 to 0.95]	0.0 [−0.42 to 0.54]	0.085
Base excess [%]-change	−35.9 [−124.14 to 30.23]	−4.1 [−27.78 to 34.83]	−50.0 [−122.35 to 36.25]	−18.6 [−69.84 to 33.71]	−41.7 [−162.66 to 6.24]	0.427

MARS: molecular adsorbent recirculating system; ADVOS: advanced organ support system; SPAD: single pass albumin dialysis; OPAL: open albumin; INR: international normalized ratio.