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. 2023 Sep 6;15(2):2252764. doi: 10.1080/19490976.2023.2252764

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — A. muciniphila supplement inhibited extensive microglial activation and synaptic engulfment in the hippocampus of SD mice.

(a) Representative immunofluorescence images of microglia (Iba1+) in the hippocampus of Con/V, Con/AKK, SD/V and SD/AKK mice. Scale bar = 50 μm. n = 22-27 areas per group. (b) The density of Iba1+ cells in the hippocampus of each group.(c) Representative images of C1q (Green) immunoreactivity in the hippocampus of each group and (d) quantification. Scale bar = 10 μm. (e, f and g) Iba1 and CD68 co-stain in the hippocampus of each group. Scale bar = 50 μm. n = 17-18 areas per group. (h and i) Confocal and Imaris reconstruction images showing SYP puncta within Iba1+ microglia in the hippocampus in each group (white arrows). n = 6 cells per group. (One-way ANOVA with Tukey’s multiple comparison tests, *P < .05, **P < .01, ***P < .001, ****P < .0001, ns, no significant difference).