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. 2023 Sep 6;15(2):2252764. doi: 10.1080/19490976.2023.2252764

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — The effects of A. muciniphila colonization on metabolic dysfunction-associated SD in mice.

(a) Body weight and (b) food intake of control and AKK supplementary mice. n = 12 mice per group. (Two-tailedt-test) (c) Principal coordinates analysis (PCoA) of metabolite profiles in serum samples. (d and e) Differentiation of metabolites between the SD/V and control mice (d), and between the SD/AKK and SD mice revealed by volcano plot (e). The enrichment of representative metabolite in serum upon SD/V (f) and SD/AKK group (g). (h) Acetate and (i) butanoic acid relative levels in the serum of mice. (j and k) The exploration percentage positively correlates with gut metabolites acetate (j) and butanoic acid (k). (l and m) The concentrations of acetate and butanoic acid in the serum of mice. n = 6 mice per group. (One-way ANOVA with Tukey’s multiple comparison tests, *P < .05, **P < .01, ***P < .001, ns, no significant difference).