Table 4.

Comparison of the estimates by random-effects vs. fixed-effects models.

Groups		Hazard ratios (95% CI)
		Effects model (random)	Effects model (fixed)
Region	Israel	0.36 (0.13–0.96)	0.58 (0.46–0.72)
	USA	0.73 (0.63–0.85)	0.74 (0.68–0.79)
Age	<75 years	0.80 (0.61–1.04)	0.74 (0.68–0.80)
	≥75 years	0.68 (0.62–0.75)	0.68 (0.62–0.75)
Gender	Male	0.58 (0.25–1.39)	0.77 (0.59–1.00)
	Female	0.62 (0.36–1.08)	0.62 (0.36–1.08)
Race/ethnicity	Non-Hispanic black	1.67 (0.83–3.36)	1.34 (1.11–1.61)
	Hispanic white	1.17 (0.87–1.59)	1.13 (0.92–1.39)
	Other race/ethnicity	0.84 (0.68–1.04)	0.84 (0.68–1.04)
Dosage	≤6 doses	0.76 (0.50–1.15)	0.84 (0.75–0.94)
	>6 doses	0.61 (0.46–0.82)	0.65 (0.59–0.72)
Follow-up period	follow- up ≤ 5 years	0.46 (0.23–0.89)	0.72 (0.66–0.78)
	Follow-up >5 years	0.55 (0.32–0.94)	0.72 (0.63–0.84)
Outcome	AD	0.47 (0.30–0.75)	0.71 (0.66–0.77)
	Dementia	0.62 (0.33–1.17)	0.76 (0.64–0.91)
Total		0.55 (0.42–0.73)	0.72(0.67–0.77)