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The bidirectional nature of P2X7R. In TME, eATP stimulation promotes P2X7R to open channels that allow small cations to permeate, which is beneficial for tumor cell growth. As the concentration of eATP increases, the action time is prolonged. When the threshold value is exceeded, it will drive the nonselective macropore opening of P2X7R, the infiltration of large ions such as inflammatory cytokines, and lead to tumor cell lysis and death.
