Figure 7.

Analysis of plasma heme content in relation to hematology parameters II. The concentrations of total heme (panels A and B) presented in Figure 6 were analyzed as a function of the reticulocyte count (panel A) and the percent of HbF (panel B). The inset in panel A shows the plot of unbound heme concentrations relative to reticulocyte counts. The mean values of total and unbound heme (µM) of the samples with less or more than 15% HbF, as indicated by the horizontal dashed line, are indicated in panel B. In panel C, the counts of samples with less than 3.10⁶ RBC/µL and the indicated concentrations of total and unbound heme were analyzed in the samples with an HbF level of at least 15% and compared to the entire cohort.