Table 1.
Cerebrospinal fluid analysis | ||||
---|---|---|---|---|
Patient 1 | Cytochemical examination | Result | Autoimmune panel | Titer |
Appearance | Clear | Anti Ca2+ Channel Ab | Negative | |
White cells | 3 cells/mm3 | Aanti VGCK Ab | Negative | |
Glucose | 60.4 mg/dl | Anti GLUR3 Ab | Negative | |
Proteins | 31.8 mg/dl | Anti AMPAR1,2 Ab | Negative | |
Microbiological panel | Anti CASPR2 Ab | Negative | ||
HSV-1 | Negative | Anti LGI1 Ab | Negative | |
HSV-2 | Negative | Anti NMDAR Ab | Negative | |
HHV-6 | Negative | Anti GABAR Ab | Negative | |
HHV-7 | Negative | Anti GAD65 Ab | Negative | |
HHV-8 | Negative | Anti MOG Ab | Negative | |
CMV | Negative | Anti AQP4 Ab | Negative | |
EBV | Negative | Oligoclonal bands | Negative | |
VZV | Negative | |||
Patient 2 | Cytochemical examination | Result | Autoimmune panel | Titer |
Appearance | Clear | Anti Ca2+ Channel Ab | Negative | |
White cells | 1 cells/mm3 | Aanti VGCK Ab | Negative | |
Glucose | 54 mg/dl | Anti GLUR3 Ab | 1:2 | |
Proteins | 26 mg/dl | Anti AMPAR1,2 Ab | Negative | |
Microbiological panel | Anti CASPR2 Ab | Negative | ||
HSV-1 | Negative | Anti LGI1 Ab | Negative | |
HSV-2 | Negative | Anti NMDAR Ab | Negative | |
HHV-6 | Negative | Anti GABAR Ab | Negative | |
HHV-7 | Negative | Anti GAD65 Ab | Negative | |
HHV-8 | Negative | Anti MOG Ab | Negative | |
CMV | Negative | Anti AQP4 Ab | Negative | |
EBV | Negative | Oligoclonal bands | Negative | |
VZV | Negative |
Serum analysis | ||||
---|---|---|---|---|
Patient 1 | Autoimmune panel | Titer | ||
Anti Ca2+ Channel Ab | Negative | Anti-Ma1 Ab | Negative | |
Anti VGCK Ab | Negative | Anti-Ma2/Ta Ab | Negative | |
Anti GLUR3 Ab | Negative | Anti-CV2/CRMP5 Ab | Negative | |
Anti AMPAR1,2 Ab | Negative | Anti-Hu Ab | Negative | |
Anti CASPR2 Ab | Negative | Anti-Ri p54 Ab | Negative | |
Anti LGI1 Ab | Negative | Anti-Yo Ab | Negative | |
Anti NMDAR Ab | Negative | Anti-recoverin Ab | 1:32 | |
Anti GABAR Ab | Negative | Anti-amphiphysin Ab | Negative | |
Anti GAD65 Ab | Negative | Anti-SOX1 Ab | Negative | |
ANA | Negative | Anti-Zic4 Ab | Negative | |
ENA | Negative | Anti-titin Ab | Negative | |
Antiphospholipid antibodies | Negative | Anti-Tr Ab | Negative | |
Patient 2 | Autoimmune panel | Titer | ||
Anti Ca2+ Channel Ab | Negative | Anti-Ma1 Ab | Negative | |
Anti VGCK Ab | Negative | Anti-Ma2/Ta Ab | Negative | |
Anti GLUR3 Ab | 1:200 | Anti-CV2/CRMP5 Ab | Negative | |
Anti AMPAR1,2 Ab | Negative | Anti-Hu Ab | Negative | |
Anti CASPR2 Ab | Negative | Anti-Ri p54 Ab | Negative | |
Anti LGI1 Ab | Negative | Anti-Yo Ab | Negative | |
Anti NMDAR Ab | Negative | Anti-recoverin Ab | Negative | |
Anti GABAR Ab | Negative | Anti-amphiphysin Ab | Negative | |
Anti GAD65 Ab | Negative | Anti-SOX1 Ab | Negative | |
ANA | Negative | Anti-Zic4 Ab | Negative | |
ENA | Negative | Anti-titin Ab | Negative | |
Antiphospholipid antibodies | Negative | Anti-Tr Ab | Negative |
AMPAR, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ANA, antinuclear antibody; AQP4, aquaporin-4; CASPR2, anti-contactin-associated protein-like 2; CMV, cytomegalovirus; CV2/CRMP5, collapsin response mediator protein; EBV, Epstein-Barr virus; GABAR, anti-y-aminobutyric acid-beta-receptor 1; ENA, extractable nuclear antigen; GAD65, glutamic acid decarboxylase 65; GLUR3, glutamate receptor 3; HSV, herpes simplex virus; HHV, human herpes virus; LGI1, leucine-rich glioma inactivated 1; MOG, myelin oligodendrocyte glycoprotein; NMDAR, N-methyl-D-aspartate receptor; SOX1, superoxide dismutase 1; Tr, thyrotropin; VGCK, voltage-gated potassium channel; VZV, varicella-zoster virus; Zic4, zinc finger protein.
Bold numbers are used to identify pathological findings.