Figure 2.

All-cause mortality risk by septile of soluble α-klotho using S4 as reference group among (A) total population, (B) individuals with estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m², and (C) those with eGFR < 60 ml/min/1.73 m². Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, race/ethnicity, body mass index (BMI), survey cycle, estimated glomerular filtration rate (eGFR), diabetes, hypertension. Model 3: adjusted for age, sex, race/ethnicity, BMI, survey cycle, eGFR, diabetes, hypertension, cardiovascular disease (CVD), stroke, hepatitis C virus (HCV) infection, smoking status. Model 4: adjusted for age, sex, race/ethnicity, BMI, survey cycle, eGFR, diabetes, hypertension, CVD, stroke, HCV infection, smoking status, family income-to-poverty ratio.