Table 2.
Factors associated with soluble α-klotho levels by weighted multiple linear regression analysis.
| Parameter | Estimate (B) | Std. Error | 95% CI lower bound | 95% CI upper bound | p value |
|---|---|---|---|---|---|
| Intercept | 709.3 | 38.7 | 632.2 | 786.3 | <0.001 |
| Age | -0.9 | 0.4 | -1.6 | -0.2 | <0.05 |
| Female (vs. male) | 35.1 | 6.5 | 22.2 | 48.0 | <0.001 |
| Race/ethnicity | |||||
| White People | Reference | ||||
| Black People | 85.6 | 12.4 | 60.9 | 110.2 | <0.001 |
| Hispanic | 9.5 | 9.7 | -9.7 | 28.7 | >0.05 |
| Other | -4.4 | 12.4 | -29.1 | 20.4 | >0.05 |
| BMI | -1.6 | 0.6 | -2.7 | -0.5 | <0.01 |
| eGFR | 1.7 | 0.2 | 1.3 | 2.1 | <0.001 |
| Smoking status | |||||
| Never | 65.1 | 9.3 | 46.6 | 83.7 | <0.001 |
| Former | 38.7 | 9.4 | 19.9 | 57.5 | <0.001 |
| Current smoker | Reference | ||||
| Diabetes | 10.1 | 9.6 | -9.0 | 29.3 | >0.05 |
| Hypertension | 2.6 | 7.1 | -11.6 | 16.7 | >0.05 |
| Cardiovascular disease | -0.3 | 10.1 | -20.5 | 19.8 | >0.05 |
| Stroke | -16.7 | 12.7 | -42.0 | 8.5 | >0.05 |
| HCV infection | 171.4 | 39.9 | 91.9 | 250.9 | <0.001 |
eGFR, estimated glomerular filtration rate; BMI, body mass index; HCV, hepatitis C virus.