Table 3.
All-cause mortality risk by septile of soluble α-klotho levels .
| Parameter | Crude model | Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|---|---|
| No. of events | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| All-cause mortality | ||||||
| S1 (n=1940) | 297 | Reference | Reference | Reference | Reference | Reference |
| S2 (n=1943) | 226 | 0.71 (0.56-0.90) ** | 0.72 (0.57-0.93) * | 0.75 (0.58-0.98) * | 0.75 (0.57-0.97) * | 0.74 (0.57-0.97) * |
| S3 (n=1939) | 202 | 0.64 (0.47-0.86) ** | 0.68 (0.52-0.90) ** | 0.71 (0.53-0.96) * | 0.72 (0.54-0.97) * | 0.71 (0.53-0.96) * |
| S4 (n=1944) | 193 | 0.62 (0.48-0.79) *** | 0.69 (0.54-0.88) ** | 0.69 (0.54-0.89) ** | 0.69 (0.54-0.89) ** | 0.69 (0.53-0.89) ** |
| S5 (n=1939) | 198 | 0.62 (0.49-0.79) *** | 0.70 (0.55-0.89) ** | 0.72 (0.56-0.92) ** | 0.76 (0.59-0.98) * | 0.73 (0.57-0.94) * |
| S6 (n=1942) | 157 | 0.54 (0.40-0.73) *** | 0.64 (0.47-0.86) ** | 0.64 (0.48-0.86) ** | 0.66 (0.49-0.89) ** | 0.65 (0.48-0.90) ** |
| S7 (n=1936) | 217 | 0.73 (0.59-0.90) ** | 0.98 (0.79-1.21) | 0.98 (0.79-1.22) | 1.00 (0.81-1.23) | 0.95 (0.76-1.18) |
Model 1: adjusted for age and sex.
Model 2: adjusted for age, sex, race/ethnicity, body mass index (BMI), survey cycle, estimated glomerular filtration rate (eGFR), diabetes, hypertension.
Model 3: adjusted for age, sex, race/ethnicity, BMI, survey cycle, eGFR, diabetes, hypertension, cardiovascular disease (CVD), stroke, hepatitis C virus (HCV) infection, smoking status.
Model 4: adjusted for age, sex, race/ethnicity, BMI, survey cycle, eGFR, diabetes, hypertension, CVD, stroke, HCV infection, smoking status, family income-to-poverty ratio.
*p<0.05; **p<0.01; ***p<0.001.