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. 2023 Aug 24;14:1234427. doi: 10.3389/fphys.2023.1234427

TABLE 6.

Linear regression models modeling the association of biomarkers with BP and BPV unweighted data.

Adjusted for age, sex, race, education, income, and smoking status Additionally adjusted for any comorbidity and any medication
Model 1 Model 2 Model 3 Model 4
Biomarker R2 BP BP p R2 BP BP p BPV BPV p R2 BP BP p R2 BP BP p BPV BPV p
Est Est Est Est Est Est
Seated baseline
ln IL-6
Systolic 0.14 0.003 <.001 0.14 0.004 <.001 −0.035 0.104 0.15 0.003 <.001 0.16 0.003 <.001 −0.024 0.254
Diastolic 0.13 0.002 0.211 0.14 0.003 0.069 −0.095 <.001 0.15 0.002 0.205 0.16 0.003 0.084 −0.076 <.001
ln e-Selectin
Systolic 0.06 0.002 0.018 0.06 0.002 0.022 0.004 0.776 0.07 0.001 0.025 0.07 0.001 0.036 0.010 0.510
Diastolic 0.06 0.002 0.026 0.06 0.003 0.018 −0.020 0.215 0.07 0.002 0.028 0.07 0.002 0.024 −0.009 0.555
ln s-ICAM
Systolic 0.06 0.000 0.703 0.06 0.000 0.489 −0.023 0.059 0.06 0.000 0.751 0.06 0.000 0.542 −0.022 0.081
Diastolic 0.06 0.001 0.213 0.06 0.001 0.116 −0.032 0.014 0.06 0.001 0.211 0.06 0.001 0.120 −0.029 0.027
ln Epinephrine
Systolic 0.39 −0.002 0.386 0.40 −0.002 0.252 0.076 0.080 0.40 −0.002 0.356 0.40 −0.002 0.211 0.088 0.043
Diastolic 0.39 0.000 0.952 0.39 −0.001 0.862 0.085 0.066 0.40 −0.000 0.958 0.40 −0.001 0.724 0.106 0.023
ln Norepinephrine
Systolic 0.39 0.002 0.085 0.39 0.002 0.139 0.044 0.181 0.39 0.002 0.103 0.39 0.002 0.185 0.056 0.089
Diastolic 0.39 0.004 0.082 0.39 0.004 0.113 0.036 0.305 0.39 0.004 0.098 0.39 0.003 0.158 0.058 0.098
ln Cortisol
Systolic 0.15 0.001 0.617 0.15 0.000 0.923 0.062 0.014 0.16 0.001 0.523 0.17 0.000 0.764 0.050 0.045
Diastolic 0.15 −0.000 0.896 0.15 −0.001 0.607 0.075 0.005 0.16 −0.000 0.973 0.16 −0.001 0.750 0.054 0.043

The bold value means significant at < 0.05.