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. 2023 Aug 24;10:1253689. doi: 10.3389/fmolb.2023.1253689

TABLE 1.

Library design statistics.

Starting DARPin PDB ID Variable positions a Set b Nseq c dseq d dchemseq e Qnet f
Common framework 4drx [F] ASLTYIMSLITWDIMKFK M 1,429 9 7 −6.8
Known binder 4k5a [B] KYDMNFMRDNFWKQQKFK P 284 12 7 −4.0
Known binder 4k5b [B] RFWMEDLTMKIVYWEKFK P 500 9 6 −6.0
a

Position IDs, in the same order: 45, 46, 48, 56, 57, 78, 79, 81, 89, 90, 111, 112, 114, 122, 123, 144, 145 and 147.

b

M: mutation; P: permutation.

c

Number of sequences.

d

Closest distance from a design to a known binder interface at 18 variable positions, expressed as number of substitutions.

e

Closest distance from a design to a known binder interface at 18 variable positions, expressed as number of homology group changes.

f

Mean net charge of designs within the set.

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