TABLE 1.
Starting DARPin | PDB ID | Variable positions a | Set b | Nseq c | dseq d | dchemseq e | Qnet f |
---|---|---|---|---|---|---|---|
Common framework | 4drx [F] | ASLTYIMSLITWDIMKFK | M | 1,429 | 9 | 7 | −6.8 |
Known binder | 4k5a [B] | KYDMNFMRDNFWKQQKFK | P | 284 | 12 | 7 | −4.0 |
Known binder | 4k5b [B] | RFWMEDLTMKIVYWEKFK | P | 500 | 9 | 6 | −6.0 |
Position IDs, in the same order: 45, 46, 48, 56, 57, 78, 79, 81, 89, 90, 111, 112, 114, 122, 123, 144, 145 and 147.
M: mutation; P: permutation.
Number of sequences.
Closest distance from a design to a known binder interface at 18 variable positions, expressed as number of substitutions.
Closest distance from a design to a known binder interface at 18 variable positions, expressed as number of homology group changes.
Mean net charge of designs within the set.