TABLE 4.
Comparison of recommended doses in different countries.
| Country | Intravenous infusion | Oral administration | Recommendations for dose adjustment | ||
|---|---|---|---|---|---|
| Loading dose | Maintenance dose | Loading dose | Maintenance dose | ||
| China | 6 mg/kg every 12 h | 4 mg/kg every 12 h | weighing more than 40 kg: 400 mg every 12 h; weighing less than 40 kg: 200 mg every 12 h | weighing more than 40 kg: 200 mg every 12 h; weighing less than 40 kg: 100 mg every 12 h | The dosage should be modified for each patient based on weight, disease features, drug metabolism, liver, kidney, and Ctrough (Chen et al., 2018) |
| United States | 6 mg/kg every 12 h | 4 mg/kg every 12 h | 6 mg/kg every 12 h (Intravenous infusion) | weighing more than 40 kg: 200 mg every 12 h; weighing less than 40 kg: 100/150 mg every 12 h | The prescribed dose interval should be modified according to the patient’s medication metabolism, liver function, and renal function (Patterson et al., 2016) |
| EU | 6 mg/kg every 12 h | 4 mg/kg twice daily | weighing more than 40 kg: 400 mg every 12 h; weighing less than 40 kg: 200 mg every 12 h | Weighing more than 40 kg: 200 mg twice daily; weighing less than 40 kg: 100 mg twice daily | Individuals with compromised liver function and drug interactions should have their dosages customized based on their Ctrough levels (Ullmann et al., 2018) |
| United Kingdom | 6 mg/kg every 12 h | 4 mg/kg twice daily | weighing more than 40 kg: 400 mg every 12 h; weighing less than 40 kg: 200 mg every 12 h | weighing more than 40 kg: 200 mg twice daily; weighing less than 40 kg: 100 mg twice daily | The dosage should be adjusted accordingly, taking into consideration the patient’s drug metabolism, potential drug interactions, as well as liver and kidney function (Ashbee et al., 2014) |
| Japan | 6 mg/kg every 12 h | 4 mg/kg twice daily | weighing more than 40 kg: 300 mg twice daily (For the first 2 days). weighing less than 40 kg: 150 mg twice daily (For the first 2 days) | weighing more than 40 kg: 150/200 mg twice daily; weighing less than 40 kg: 100 mg twice daily | Ctrough monitoring is advised, along with tailored dosage and dosing interval adjustments for VRZ based on genetic polymorphism and drug metabolism (Roberts et al., 2012) |