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. 2023 Jul 13;51(16):8447–8462. doi: 10.1093/nar/gkad594

Figure 3.

Figure 3.

A Tyr at position −5 of ZF5 and ZF8 of CTCF. (A) Sequence alignment of four fingers containing a Tyr at position −5, ZF3 of ZBTB7A, ZF5 and ZF8 of CTCF, and ZF4 of HIC2. The circled basic residues are unique to ZF8 of CTCF. (B) Superimpositions of ZF5 of CTCF with ZF3 of ZBTB7A. The Tyr at position −5 adopted two alternative conformations. (C) Comparison of ZF5 and ZF8 of CTCF. (D) Comparison of ZF5 of CTCF and ZF4 of HIC2. (E) In HIC2, Y at −5 and R at −7 positions interact with the same G:C base pair.