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. 2023 Jul 13;51(16):8447–8462. doi: 10.1093/nar/gkad594

Figure 4.

Figure 4.

Aspartate for cytosine and glutamate for 5-methylcytosine. (A) Either a CpG or CpA site can occur at DNA positions 2 and 3 or 12 and 13. (B) Examples of ZF7 interaction with CpA (PDB 8SSS) or CpG (PDB 5K5L). The interaction of Val454–methyl of thymine of the bottom strand also applies to the hemi-methylated 5mCpG at the bottom strand. (C) Examples of ZF4–ZF3 interactions with unmethylated CpG (PDB 8SSS) or fully methylated 5mCpG (PDB 5T00). The Ser364–methyl interaction applies to bottom strand TpG, hemi- or fully methylated 5mCpG.