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. 2023 Jul 13;51(16):8447–8462. doi: 10.1093/nar/gkad594

Figure 6.

Figure 6.

Structure of CTCF ZF3–ZF11 in complex with DNA. (A) A 35-bp DNA oligo was used in the crystallization with ZF3–ZF11. The DNA base pairs are numbered from 1 to 17 (to the left) for recognition by ZF3–ZF7 and from −1 to −18 (to the right) for recognition by ZF8–ZF11. (B) Structure of CTCF ZF3–ZF11 in complex with DNA. ZF8 is in the center. (C) ZF8 has eight basic residues (including the linker) engaging in DNA phosphate backbone interactions. (D) Realignment between the predicted DNA-binding specificity of CTCF ZF1–ZF11 with the actual consensus sequence that has extended 5′ upstream sequence.