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. 2023 Jul 13;51(16):8447–8462. doi: 10.1093/nar/gkad594

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — ZF9–ZF11 have cross-strand interactions contributing to base recognition. (A) Schematic of interactions involving ZF9–ZF11 of CTCF. (B) ZF9 spans 4 bp, with Gln506 (−7) and Arg508 (−5) making cross-strand base interactions with adenine and guanine, respectively. (C) ZF10 spans 4 bp, with Gln536 (−5) making cross-strand adenine interaction. Met540 of ZF10 is further away from the viewer and invisible at this viewpoint. (D) Arg566 of ZF11 crisscrosses two guanines at two neighboring base pairs. (E, F) Gln264 at −5 of ZF2 in ZNF410 makes a cross-strand adenine-specific interaction.