Table 2.
Meta-analyses of serum lipid levels and disease activity.
| Endpoints | No. studies | Pooled proportion using random-effects model | Heterogeneity | ||
|---|---|---|---|---|---|
| WMD | P | I 2 | P | ||
| Active IBD versus inactive IBD | |||||
| TC level | 5 | −0.454, 95%CI = −0.722 to −0.187 | 0.001 | 0% | 0.421 |
| HDL-c level | 4 | −0.248, 95%CI = −0.542 to 0.047 | 0.099 | 87.6% | <0.001 |
| LDL-c level | 4 | −0.225, 95%CI = −0.445 to −0.005 | 0.045 | 0% | 0.740 |
| TG level | 4 | −0.129, 95%CI = −0.273 to 0.015 | 0.080 | 0% | 0.868 |
| Active CD versus active UC | |||||
| TC level | 2 | −0.311, 95%CI = −0.648 to 0.026 | 0.071 | 0% | 0.435 |
| HDL-c level | 2 | -0.075, 95%CI = −0.196 to 0.046 | 0.226 | 0% | 0.891 |
| LDL-c level | 2 | −0.393, 95%CI = −0.666 to −0.121 | 0.005 | 0.7% | 0.316 |
| TG level | 2 | 0.077, 95%CI = −0.148 to 0.302 | 0.502 | 26.3% | 0.244 |
| Inactive CD versus inactive UC | |||||
| TC level | 2 | −0.629, 95%CI = −0.966 to −0.291 | <0.0001 | 0% | 0.683 |
| HDL-c level | 2 | −0.059, 95%CI = −0.176 to 0.058 | 0.324 | 0% | 0.378 |
| Mild active UC versus non-mild UC | |||||
| TC level | 2 | 0.462, 95%CI = 0.176 to 0.748 | 0.002 | 0% | 0.504 |
| LDL-c level | 2 | 0.346, 95%CI = 0.084 to 0.609 | 0.010 | 0% | 0.647 |
WMD, Weighted mean difference; CI, Confidence Interval; IBD, inflammatory bowel disease; CD, Crohn’s disease; UC, ulcerative colitis; TC, total cholesterol; HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; TG, triglyceride.
The p-value was statistically significant.