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. 2023 Sep 4;55(9):1567–1578. doi: 10.1038/s41588-023-01476-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, UMAP showing clustering analysis and annotations of WT, MCM2-2A and MCM2-R cells. b, WT, MCM2-2A and MCM2-R cells projected on the common UMAP. Colored lines represent cell density. c, Relative abundance of main subpopulations shown in a for each cell line. P values were derived from chi-square tests comparing cell counts for the clusters of interest with the cell counts of all other clusters. n = number of cells; WT (n = 15,181), MCM2-2A#2 (n = 15,488) examined over two biological replicates, MCM2-R#2 (n = 4487). d, Pseudotime analysis showing main trajectories between clusters. e, Cell-cycle-separated single cells projected on UMAP. Colored lines represent cell density.