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. 2023 Sep 4;55(9):1531–1541. doi: 10.1038/s41588-023-01480-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Force-atlas representation of 17517 cells from healthy donor (n = 9), MF (n = 8) and TP53-sAML patients (n = 14; preleukemic: TP53-WT, leukemic: TP53 multi-hit) according to patient type (left) or donor (right). b, Heatmap of the top 100 differentially expressed genes identified between TP53 multi-hit cells and preleukemic (TP53-WT; “preLSCs”), MF and healthy donor (HD) cells. The type of donor, donor ID and TP53 genotype is indicated on the top of the heatmap for each single cell. c, Venn diagram of the overlapping p53-target genes from Fischer et al⁸⁵ and differentially expressed genes between TP53-multi-hit cells and TP53-WT cells. “p” indicates hypergeometric test p-value. d, GSEA analysis of Lin⁻CD34⁺ TP53 multi-hit LSC or erythroid-biased cells (Related to Fig. 2a) from TP53-sAML patients, compared to Lin⁻CD34⁺ healthy donor, MF and preLSCs. Heatmap indicates NES from selected genesets with FDR q-value < 0.25. NES: Normalized Enrichment Score; FDR: False Discovery Rate. NS: non-significant.