Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 4;55(9):1531–1541. doi: 10.1038/s41588-023-01480-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a–d, M-FISH karyotype analysis of LSK-derived cultured cells from CD45.1 (Trp53^R172H/+) or CD45.2 (WT) LSKs obtained at terminal end-point from chimeric control or poly(I:C) treated mice as in Fig. 5a (n = 3 mice per group, n = 2 independent experiments). a, Percentage of normal and abnormal karyotypes in each experimental group. At the top of each bar, n indicates number of metaphases scored. b, Type of karyotypic aberrations per hundred metaphases. c, Violin plot of the number of karyotypic aberrations per single Trp53^R172H/+ cell stratified by treatment. d, Representative karyotypes from Trp53^R172H/+ cells obtained from control or poly(I:C) chimeras (yellow arrows indicate partial chromosome gains and green arrows indicate whole chromosome gains). Two-sided Fisher’s exact test was carried out to calculate P values; in c, Fisher’s exact test was calculated by testing metaphases with 3 or more aberrations versus metaphases with 0–2 aberrations. e, Schematic of the proposed model of TP53-mutant-driven transformation in MPN. Created with BioRender.com.

Source data