Table 3.
Surgical data.
| Characteristic | N | Platinum sensitive N = 116 (60%)1 |
Platinum resistant N = 76 (40%)1 |
p-value2 |
|---|---|---|---|---|
| History of HIPEC | 191 | 0.007 | ||
| None | 102 (88%) | 74 (99%) | ||
| Yes | 14 (12%) | 1 (1.3%) | ||
| Missing | 0 | 1 | ||
| History of CRS | 185 | 0.047 | ||
| None | 36 (33%) | 15 (20%) | ||
| Yes | 73 (67%) | 61 (80%) | ||
| Missing | 7 | 0 | ||
| PCI (at 1st PIPAC) | 183 | 16 (9, 24) | 24 (17, 30) | <0.001 |
| Missing | 9 | 0 | ||
| PCI (at 2nd or 3rd PIPAC) | 128 | 12 (6, 19) | 20 (6, 28) | 0.009 |
| Missing | 36 | 28 | ||
| Cytology (at 1st PIPAC) | 115 | 0.76 | ||
| positive | 36 (63%) | 35 (60%) | ||
| Missing | 59 | 18 | ||
| N PIPAC (by patient) | 192 | 3 (1, 3) | 2 (1, 3) | 0.016 |
| PIPAC (2 cycles)* | 192 | 20 (17%) | 18 (24%) | 0.27 |
| PIPAC (3 cycles)* | 192 | 66 (57%) | 30 (39%) | 0.018 |
| Overall complications | 192 | 22 (19%) | 21 (28%) | 0.16 |
| Severe complications (Clavien ≥3)# | 192 | 5 (4.3%) | 6 (7.9%) | 0.35 |
| Open laparoscopy related¶ | 184 | 1 (0.9%) | 2 (2.7%) | 0.56 |
| Missing | 5 | 3 | ||
| Mortality at 30-days | 191 | 3 (2.6%) | 0 (0%) | 0.28 |
| Missing | 1 | 0 |
1 n (%); Median (IQR).
2 Pearson's Chi-squared test; Wilcoxon rank sum test; Fisher's exact test; Mann-Whitney U test.
* Patients who completed at least 2 or 3 PIPAC cycles. 1 cycle = 1 PIPAC procedure.
# Clavien-Dindo classification, greater or equal than grade 3.
¶ Complications related to surgical access issue (e.g., small bowel perforation during open-laparoscopy).