Fig. 2. Epigenome-wide Association of CpGs with Bronchiolitis Severity.

A Association test quantile–quantile plot shows a departure from the null hypothesis of no association. Confounding and batch effects were well-controlled with minimal inflation (λ_{genomic control} = 1.02). The λ_{genomic control} was calculated using QCEWAS package with default setting, which is based on one-sided Chi-Square test. B Manhattan plot for the epigenome-wide association test of bronchiolitis severity. The EWAS showed that a total of 33 DMCs were identified across 22 autosomal chromosomes and two sex chromosomes. The epigenome-wide significance level after accounting for multiple testing (FDR < 0.05) is denoted by the red line. DMC, differentially methylated CpG; EWAS, epigenome-wide association study; FDR, false discovery rate.