Table 2.
Thirty-three severity-related CpG probes differentially methylated in infant hospitalized with bronchiolitis
| CpG probe | Chromosome | Position | Effect estimate | P-value | FDR | Gene/nearest gene | Gene region feature category |
|---|---|---|---|---|---|---|---|
| cg03361294 | 14 | 57051003 | −0.58 | 1.14 × 10−12 | 9.08 × 10−7 | TMEM260 | Body |
| cg09541576 | 2 | 44873248 | −0.31 | 5.83 × 10−12 | 2.31 × 10−6 | C2orf34 | Body |
| cg15135194 | 6 | 133070524 | 0.44 | 1.57 × 10−10 | 4.15 × 10−5 | VNN2 | Body |
| cg04175911 | 10 | 99172893 | −0.17 | 6.70 × 10−10 | 1.33 × 10−4 | RRP12a | 5’UTRb |
| cg05639088 | 2 | 208176244 | −0.33 | 9.14 × 10−10 | 1.45 × 10−4 | LINC01802a | TSS1500b;3’UTRb |
| cg02936755 | 22 | 25771833 | −0.28 | 1.79 × 10−9 | 2.37 × 10−4 | LRP5L | 5’UTR |
| cg17555274 | 20 | 39122378 | −0.33 | 2.58 × 10−9 | 2.93 × 10−4 | SNORD112a | Unknown |
| cg25238420 | 12 | 47552760 | −0.29 | 2.98 × 10−9 | 2.96 × 10−4 | PCED1B | 5’UTR |
| cg20292908 | 5 | 172203421 | −0.42 | 4.19 × 10−9 | 3.70 × 10−4 | DUSP1a | 5’UTRb |
| cg27167895 | 4 | 88818173 | 0.29 | 7.36 × 10−9 | 5.85 × 10−4 | MEPEa | Unknown |
| cg16222694 | 13 | 29657404 | −0.29 | 2.36 × 10−8 | 1.70 × 10−3 | MTUS2 | Body |
| cg24346915 | 22 | 37506589 | −0.45 | 3.25 × 10−8 | 2.15 × 10−3 | TMPRSS6 | TSS1500 |
| cg12547959 | 5 | 14326153 | 0.40 | 3.60 × 10−8 | 2.20 × 10−3 | TRIO | Body |
| cg09432792 | 16 | 56352311 | 0.45 | 1.21 × 10−7 | 6.88 × 10−3 | GNAO1 | Body |
| cg13132442 | 2 | 97464277 | −0.29 | 1.40 × 10−7 | 7.20 × 10−3 | CNNM4 | Body |
| cg15002347 | 1 | 186590321 | −0.26 | 1.45 × 10−7 | 7.20 × 10−3 | PTGS2a | Unknown |
| cg07475825 | 6 | 84577581 | −0.37 | 1.95 × 10−7 | 9.13 × 10−3 | CYB5R4 | Body |
| cg05790772 | X | 144114285 | −0.75 | 2.25 × 10−7 | 9.47 × 10−3 | SPANXN1a | Unknown |
| cg27459630 | 17 | 28019440 | −0.33 | 2.27 × 10−7 | 9.47 × 10−3 | SSH2 | Body |
| cg12896170 | 6 | 28890069 | −0.29 | 2.54 × 10−7 | 1.01 × 10−2 | TRIM27 | Body |
| cg00052684 | 6 | 35694245 | −0.37 | 2.73 × 10−7 | 1.03 × 10−2 | FKBP5 | 5’UTR |
| cg08370869 | 1 | 193648305 | −0.28 | 3.35 × 10−7 | 1.21 × 10−2 | CDC73a | 5’UTRb |
| cg08552853 | 2 | 102875372 | −0.23 | 4.33 × 10−7 | 1.50 × 10−2 | IL1RL2a | Unknown |
| cg15848159 | 4 | 85791643 | 0.29 | 4.98 × 10−7 | 1.65 × 10−2 | WDFY3 | 5’UTR |
| cg03574890 | 1 | 151284129 | −0.20 | 5.46 × 10−7 | 1.67 × 10−2 | PI4KB | Body;5’UTR |
| cg22885409 | 11 | 102470832 | −0.21 | 5.40 × 10−7 | 1.67 × 10−2 | MMP20 | 3’UTRb |
| cg15920942 | 2 | 70743881 | −0.15 | 5.78 × 10−7 | 1.70 × 10−2 | TGFA | Body |
| cg01680062 | 21 | 36185960 | −0.23 | 7.66 × 10−7 | 2.17 × 10−2 | RUNX1 | Body |
| cg20361768 | 3 | 156819083 | −0.27 | 9.76 × 10−7 | 2.67 × 10−2 | LINC00880 | Body |
| cg01363387 | 5 | 95938059 | −0.20 | 1.02 × 10−6 | 2.71 × 10−2 | LOC101929710 | Body |
| cg02534167 | 2 | 207987951 | 0.13 | 1.44 × 10−6 | 3.68 × 10−2 | KLF7 | Body |
| cg03489069 | 2 | 228236715 | −0.26 | 1.56 × 10−6 | 3.75 × 10−2 | TM4SF20 | Body |
| cg09412707 | 4 | 26085653 | −0.24 | 1.55 × 10−6 | 3.75 × 10−2 | RBPJa | Unknown |
CpG cytosine-phosphate-guanine, FDR false discovery rate, TSS transcription-start site, UTR untranslated region.
aNo gene is mapped based on CpG location, nearest genes are shown.
bAnnotated based on the GENCODE v12 database. All others are annotated based on University of California, Santa Cruz (UCSC) RNA reference sequences collection (RefSeq).