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. 2023 Sep 7;8:132. doi: 10.1038/s41541-023-00728-5

Fig. 7. Mosaic VLPs immunization elicits T-cell responses in mice against H1N1- and H3N2-representative viruses.

Fig. 7

A Splenocytes isolated from immunized BALB/c mice in each group on days 35 were plated in ELISpot wells to detect IFN-γ and IL-4 cytokine-producing cells. B, C Splenocytes restimulated with inactive A/Puerto Rico/8/34 (PR8) and A/Aichi/2/1968 (X-31) virus, analyzed for cellular immunity using an IFN-γ and IL-4 ELISpot assays. Data are presented as the mean with standard error (SEM) (n = 5; one-way ANOVA with Tukey multiple comparison), *P < 0.05, **P < 0.01.