Fig. 2.

Simplified diagram showing cerebellar connections with feeding circuits in the brain. The hypothalamic nuclei are central to a network of brain regions which regulate appetite. Distinct subtypes of neurons in the arcuate (ARC) nucleus of the hypothalamus are involved in the initiation (AgRP neurons) or cessation of food consumption (POMC neurons) via their inputs to the other hypothalamic nuclei including the paraventricular hypothalamic nucleus (PVN), ventromedial hypothalamic nucleus (VMH), lateral hypothalamic nucleus (LH), and dorsomedial hypothalamic nucleus (DMH). Short-term appetite regulation involves the parabrachial nucleus (PBN) and the solitary tract nucleus (NTS) of the brainstem, which respond to feedback from the gut and form connections with the hypothalamus to initiate satiation. The cerebellum has reciprocal connections with the VMH, LH, PBN and NTS, and sends inhibitory projections to the DMH