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. 2023 Aug 21;26(9):107697. doi: 10.1016/j.isci.2023.107697

Figure 1.

Figure 1

Equal distributions of cholesterol high and low-converter types among humans with and without obesity

(A) Sterol and stanol concentrations as determined by LC-MS/HRMS in 28 fecal samples from the KETO study participants before dietary intervention.

(B) Negative correlation (Spearman’s rank) between fecal coprostanol and cholesterol concentrations and bimodal distribution of cholesterol high (N = 17), intermediate (N = 4) and low-converter (N = 7) types, as classified based on the fecal coprostanol/cholesterol ratio.

(C and D) Comparable negative correlations (Spearman’s rank) between the fecal concentrations of the phytosterols sitosterol and campesterol and the corresponding stanol conversion products stigmastanol (n = 26), and 5β-campestanol (n = 23).

(E) Similar fecal sterol and stanol concentration profiles in individuals with obesity from the CARBFUNC study before dietary intervention (n = 145 samples), compared to lean KETO study participants (N = 89/26/30 for cholesterol high/intermediate/low-converters).

(F) Negative correlation (Spearman’s rank) of fecal coprostanol and cholesterol concentrations in CARBFUNC study participants and bimodal distribution into high and low-converter types. Spearman’s rank correlation, Benjamini-Hochberg (BH) corrected: q > 0.05 ns, q < 0.01 ∗∗, q < 0.001 ∗∗∗. Pooled data are represented as mean ± SD.