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. 2023 Apr 27;28(9):827–e822. doi: 10.1093/oncolo/oyad096
Trial Information
Disease Esophageal or GEJ cancer
Stage of disease/treatment Stage IV
Prior therapy One line of prior systemic therapy
Type of study Phase II randomized
Primary endpoint Median PFS
Secondary endpoints Toxicity, median OS, ORR
Investigator’s analysis Level of activity did not meet planned end point
Additional details of endpoints or study design Patients were randomized 1:1 to arm A (paclitaxel) or arm B (paclitaxel plus cixutumumab).