Abstract
The parents of 226 of the 360 patients with anencephalus or spinal bifida or both, born in Belfast 1964 to 1968, were visited to document the occurrence of these malformations among other relatives. The proportions of sibs with anencephalus and spina bifida were 10.41% for spina bifida index patients and 6.4% for anencephalus. For patients born after the index patients, the proportions were 12.19% and 6.35%, respectively. The overall incidence of either malformation among sibs was 8.87%. This estimate is higher than the 4 to 5% commonly reported and is probably related to the specific background of the Northern Ireland population, which is known to have the highest incidence of CNS malformations in the United Kingdom. The substantial size of this risk indicates the importance of amniocentesis for monitoring subsequent pregnancies of women who have had one child with a CNS malformation.
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Selected References
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- Carter C. O., David P. A., Laurence K. M. A family study of major central nervous system malformations in South Wales. J Med Genet. 1968 Jun;5(2):81–106. doi: 10.1136/jmg.5.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter C. O., Evans K. Spina bifida and anencephalus in greater London. J Med Genet. 1973 Sep;10(3):209–234. doi: 10.1136/jmg.10.3.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter C. O., Roberts J. A. The risk of recurrence after two children with central-nervous-system malformations. Lancet. 1967 Feb 11;1(7485):306–308. doi: 10.1016/s0140-6736(67)91240-8. [DOI] [PubMed] [Google Scholar]
- Creasy M. R., Alberman E. D. Congenital malformations of the central nervous system in spontaneous abortions. J Med Genet. 1976 Feb;13(1):9–16. doi: 10.1136/jmg.13.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elwood J. H., Nevin N. C. Anencephalus and spina bifida in Belfast (1964-1968). Ulster Med J. 1973;42(2):213–222. [PMC free article] [PubMed] [Google Scholar]
- Elwood J. H., Nevin N. C. Factors associated with anencephalus and spina bifida in Belfast. Br J Prev Soc Med. 1973 May;27(2):73–80. doi: 10.1136/jech.27.2.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Janerich D. T., Piper J. Shifting genetic patterns in anencephaly and spina bifida. J Med Genet. 1978 Apr;15(2):101–105. doi: 10.1136/jmg.15.2.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MacHenry J. C., Nevin N. C., Merrett J. D. Comparison of central nervous system malformations in spontaneous absortions in Northern Ireland and south-east England. Br Med J. 1979 May 26;1(6175):1395–1397. doi: 10.1136/bmj.1.6175.1395. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nevin N. C., McDonald J. R., Walby A. L. A comparison of neural tube defects identified by two independent routine recording systems for congenital malformations in Northern Ireland. Int J Epidemiol. 1978 Dec;7(4):319–321. doi: 10.1093/ije/7.4.319. [DOI] [PubMed] [Google Scholar]
- Richards I. D., McIntosh H. T., Sweenie S. A genetic study of anencephaly and spina bifida in Glasgow. Dev Med Child Neurol. 1972 Oct;14(5):626–639. doi: 10.1111/j.1469-8749.1972.tb02645.x. [DOI] [PubMed] [Google Scholar]