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. 2023 Sep 4;96:104788. doi: 10.1016/j.ebiom.2023.104788

Fig. 4.

Fig. 4

Kinetics of S1-specific IgG, S-specific memory B cells and plasmablasts in high- and low-responder vaccinees. Kinetic of S1-specific IgG (green line, in BAU/mL), S protein-specific memory B cells (as % of total B memory cells, red line) and plasmablasts (PB; as % of total CD19+ B cells, black line) determined at four time points: pre-vaccination, either one week (S-specific B memory, PB) or four weeks (S1-specific IgG) post 2nd dose, six months post 2nd dose and four weeks post booster vaccination; A) in control high-responders (n = 4; S1-specific IgG >4000 BAU/mL 4 wks after 2nd dose and >1100 BAU/mL after 6 months), and B) in anti-TNF-α treated IBD low-responders with elevated IFN-γ/TNF-α baseline levels (n = 4; S1-specific IgG <2000 BAU/mL after 2nd dose and <90 BAU/mL after six months). Data points represent arithmetic mean with SEM.