Table 2.
Mean (95% CI) change over time in clinical outcomes from baseline to 12 months overall and by systolic blood pressure (SBP) control status at baseline (≥130 mm Hg vs <130 mm Hg; n=1117).a
| Variable | Baseline, mean (95% CI) | 12 months, mean (95% CI) | 12-month change, mean (95% CI) | P value | |
| Overall | |||||
|
|
SBP (mm Hg; n=1117) | 136.5 (135.8 to 137.3) | 131.8 (131.0 to 132.5) | –4.8 (–5.6 to –4.0) | <.001 |
|
|
DBPb (mm Hg; n=1117) | 82.4 (81.9 to 83.0) | 79.4 (78.9 to 79.9) | –3.0 (–3.5 to –2.5) | <.001 |
|
|
Weight (lbs; n=973) | 220.5 (217.4 to 223.7) | 214.3 (211.2 to 217.4) | –6.2 (–7.2 to –5.3) | <.001 |
|
|
BMI (kg/m2; n=966) | 35.3 (34.8 to 35.9) | 34.3 (33.8 to 34.9) | –1.0 (–1.2 to –0.9) | <.001 |
| Uncontrolled SBP ≥130 mm Hg at baseline | |||||
|
|
SBP (mm Hg; n=788) | 142.6 (141.9 to 143.4) | 134.6 (133.7 to 135.4) | –8.1 (–9.0 to –7.1) | <.001 |
|
|
DBP (mm Hg; n=788) | 85.5 (84.9 to 86.1) | 80.8 (80.1 to 81.4) | –4.7 (–5.3 to –4.1) | <.001 |
|
|
Weight (lbs; n=685) | 226.8 (222.9 to 230.6) | 220.3 (216.5 to 224.1) | –6.5 (–7.7 to –5.3) | <.001 |
|
|
BMI (kg/m2; n=681) | 36.3 (35.6 to 37.1) | 35.3 (34.6 to 36.0) | –1.1 (–1.3 to –0.9) | <.001 |
| Controlled SBP <130 mm Hg at baseline | |||||
|
|
SBP (mm Hg; n=329) | 122.0 (121.4 to 122.6) | 125.1 (124.0 to 126.2) | +3.1 (+2.0 to +4.2) | <.001 |
|
|
DBP (mm Hg; n=329) | 75.1 (74.6 to 75.7) | 76.2 (75.3 to 77.0) | +1.0 (+0.2 to +1.8) | .01 |
|
|
Weight (lbs; n=288) | 205.7 (200.6 to 210.8) | 200.1 (195.3 to 204.9) | –5.6 (–7.3 to –3.9) | <.001 |
|
|
BMI (kg/m2; n=285) | 33.0 (32.1 to 33.9) | 32.1 (31.2 to 33.0) | –0.9 (–1.2 to –0.6) | <.001 |
a12-month change=12 months–baseline; negative 12-month change indicates improvement in clinical outcomes.
bDBP: diastolic blood pressure.