Table 1. Comparison of Sinus Computed Tomography Parameters at Baseline and After 1 Year of Elexacaftor-Tezacaftor-Ivacaftor Therapy Using the Lund-Mackay Scoring System.
| Characteristic | Median (IQR)a | Effect size, r (95% CI)b | |
|---|---|---|---|
| Baseline (n = 64) | 1 Year (n = 64) | ||
| Frontal sinus | 1.5 (0.8-2.0) | 0.3 (0-0.8) | 1 (NC) |
| Anterior ethmoid | 1.0 (1.0-1.5) | 0.8 (0.5-1.0) | 0.97 (0.91-1.00) |
| Posterior ethmoid | 1.0 (0.8-1.0) | 0.7 (0.3-0.9) | 0.98 (0.93-1.00) |
| Maxillary sinus | 1.0 (1.0-1.3) | 1.0 (0.7-1.0) | 0.99 (0.94-1.00) |
| Sphenoid sinus | 1.0 (1.0-1.5) | 0.7 (0.3-1.0) | 0.98 (0.94-1.00) |
| Osteomeatal occlusion | 0 (0-0.2) | 0 (0-0) | 1.00 (NC) |
| Average total Lund-Mackay score | 5.8 (5.0-7.0) | 3.3 (2.6-4.2) | 1.00 (NC) |
Abbreviation: NC, noncalculable.
a
Calculated as the median of 3 reviewers and 2 (left and right) sides.
b
Matched-pairs rank biserial correlation coefficient; r = −1 is perfect negative correlation, r = 1 is perfect positive correlation, and r = 0 is no or negligible correlation. Noncalculable 95% CI indicates all score ranks at 1 year were less than or equal to baseline.