Table 2. Comparison of Sinus Computed Tomography Parameters at Baseline and After 1 Year of Elexacaftor-Tezacaftor-Ivacaftor Therapy, Using the Sheikh-Lind Scoring System.
| Characteristic | Median (IQR)a | Effect size, r (95% CI)b | |
|---|---|---|---|
| Baseline (n = 64)a | 1 Year (n = 64)a | ||
| Maxillary opacification | 2.3 (1.7 to 2.9) | 1.0 (1.0 to 1.0) | 0.99 (0.98 to 1.00) |
| Nasal cavity obstruction | 0.3 (0 to 0.7) | 0.2 (0 to 0.2) | 0.7 (0.47 to 0.87) |
| Mucocele | 0 (0 to 0.5) | 0 (0 to 0) | 0.87 (0.59 to 1.00) |
| Displacement of lateral nasal wall | 0 (0 to 0.2) | 0 (0 to 0) | 0.38 (−0.17 to 0.89) |
| Uncinate process absence | 1.0 (1.0 to 1.0) | 1.0 (1.0 to 1.0) | 0.02 (−0.82 to 0.70) |
| Total Sheikh-Lind score (opacification parameters) | 2.8 (2.0 to 3.9) | 1.2 (1.0 to 1.5) | 0.99 (0.97 to 1.00) |
| Total Sheikh-Lind score (with all 5 parameters) | 3.8 (3.0 to 5.0) | 2.2 (2.0 to 2.5) | 0.99 (0.97 to 1.00) |
a
Calculated as the median of 3 reviewers and 2 (left and right) sides.
b
Matched-pairs rank biserial correlation coefficient; r = −1 is perfect negative correlation, r = 1 is perfect positive correlation, and r = 0 is no or negligible correlation.