Table 2.
Univariate and multivariate analyses of mortality in patients with Pseudomonas aeruginosa infection detected from urine samples*
| Variable | Univariate | Multivariate† | |||
|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | ||
| Age | 1.025 (1.003–1.047) | 0.027 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 2.186 (1.163–4.110) | 0.015 | |||
| Comorbidity | |||||
| Pulmonary disease | 2.186 (1.15–4.153) | 0.017 | |||
| DM | 2.417 (1.287–4.542) | 0.006 | |||
| ICU stay | 4.966 (2.165–11.390) | <0.001 | 2.677 (1.105–6.485) | 0.029 | |
| Susceptibility to carbapenem | |||||
| CsPA | Reference | ||||
| Cns-nCPPA | 2.972 (1.152–7.668) | 0.024 | |||
| Cns-CPPA | 2.114 (1.025–4.363) | 0.043 | |||
| Carbapenem use | 3.978 (2.095–7.553) | <0.001 | 2.766 (1.363–5.614) | 0.005 | |
| Imipenem | - | ||||
| Meropenem | 4.206 (1.832–9.658) | <0.001 | |||
| Doripenem | 2.304 (1.074–4.943) | 0.043 | |||
| Ertapenem | 2.313 (1.106–4.836) | 0.026 | |||
| Laboratory finding | |||||
| Procalcitonin | 1.029 (0.967–1.094) | 0.374 | |||
| CRP | 1.008 (1.003–1.012) | 0.001 | |||
| WBC | 1.115 (1.062–1.170) | <0.001 | 1.070 (1.004–1.141) | 0.039 | |
| Neutrophil | 1.057 (1.026–1.089) | <0.001 | |||
| Lymphocyte | 0.929 (0.891–0.969) | <0.001 | |||
| NLR | 1.057 (1.027–1.088) | <0.001 | 1.032 (1.000–1.070) | 0.093 | |
| Glucose | 1.009 (1.004–1.015) | 0.001 | |||
| LD | 1.001 (1.000–1.002) | 0.401 | |||
*Among 499 patients, 43 (8.6%) belonged to the mortality group and the remaining 456 (91.4%) patients were designated to the survivor group.
†Variables with P<0.001 in univariate analysis were included in the multivariate analysis.
Abbreviations: CI, confidence interval; Cns-CPPA, carbapenem-non-susceptible and carbapenemase-producing P. aeruginosa; Cns-nCPPA, carbapenem-non-susceptible and non-carbapenemase-producing P. aeruginosa; CRP, C-reactive protein; CsPA, carbapenem-susceptible P. aeruginosa; DM, diabetes mellitus; ICU, intensive care unit; OR, odds ratio; WBC, white blood cell; NLR, neutrophil-to-lymphocyte ratio; LD, lactate dehydrogenase.