Table 6.
66 significant CpG-metabolite associations sorted by gene and significance
| CpG | Gene | Metabolite | Pathway | Subpathway | Effect | P-value |
|---|---|---|---|---|---|---|
| cg19693031 | TXNIP | 1,5-anhydroglucitol (1,5-AG) a | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | 0.02 | 2.93E-19 |
| cg19693031 | TXNIP | pyruvate | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | -0.02 | 4.94E-14 |
| cg19693031 | TXNIP | Glucosea | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | -0.01 | 2.09E-11 |
| cg02988288 | TXNIP;NBPF20;NBPF10 | glucose | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | -0.01 | 9.24E-07 |
| cg19693031 | TXNIP | 3-methyl-2-oxobutyrate | Amino Acid | Leucine, Isoleucine, Valine | -0.02 | 2.14E-13 |
| cg19693031 | TXNIP | 3-methyl-2-oxovalerate | Amino Acid | Leucine, Isoleucine, Valine | -0.01 | 1.23E-06 |
| cg19693031 | TXNIP | 1-carboxyethylvaline | Amino Acid | Leucine, Isoleucine, Valine | -0.01 | 9.64E-06 |
| cg19693031 | TXNIP | mannonate* | Xenobiotics | Food Component/Plant | -0.01 | 1.61E-11 |
| cg19693031 | TXNIP | Gluconatea | Xenobiotics | Food Component/Plant | -0.01 | 4.83E-08 |
| cg02988288 | TXNIP;NBPF20;NBPF10 | mannonate* | Xenobiotics | Food Component/Plant | -0.01 | 9.01E-06 |
| cg19693031 | TXNIP | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | -0.01 | 4.31E-11 |
| cg19693031 | TXNIP | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | -0.01 | 4.03E-09 |
| cg19693031 | TXNIP | alanine | Amino Acid | Alanine, Aspartate | -0.01 | 9.68E-10 |
| cg02988288 | TXNIP;NBPF20;NBPF10 | alanine | Amino Acid | Alanine, Aspartate | -0.01 | 3.02E-08 |
| cg19693031 | TXNIP | erythronate* | Carbohydrate | Aminosugar | -0.01 | 2.57E-08 |
| cg19693031 | TXNIP | Mannosea | Carbohydrate | Fructose, Mannose, Galactose | -0.01 | 9.30E-07 |
| cg19693031 | TXNIP | glutamine | Amino Acid | Glutamate | 0.01 | 1.11E-06 |
| cg19693031 | TXNIP | 2-hydroxybutyrate/2-hydroxyisobutyratea | Amino Acid | Glutathione | -0.01 | 1.66E-10 |
| cg19693031 | TXNIP | ribitol | Carbohydrate | Pentose | -0.01 | 5.98E-06 |
| cg19693031 | TXNIP | 1-carboxyethylphenylalanine | Amino Acid | Phenylalanine | -0.01 | 1.63E-06 |
| cg19693031 | TXNIP | X—24295 | Unnamed | Unnamed | -0.01 | 7.53E-15 |
| cg19693031 | TXNIP | X—24334 | Unnamed | Unnamed | -0.02 | 3.62E-12 |
| cg19693031 | TXNIP | X—12101 | Unnamed | Unnamed | -0.01 | 4.17E-09 |
| cg19693031 | TXNIP | X—14056 | Unnamed | Unnamed | -0.01 | 3.03E-08 |
| cg19693031 | TXNIP | X—19438 | Unnamed | Unnamed | -0.01 | 1.32E-07 |
| cg11969813 | P4HB | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 1.23E-08 |
| cg00683922 | PFKFB2 | 1-carboxyethylphenylalanine | Amino Acid | Phenylalanine | 0.01 | 3.57E-08 |
| cg22699725 | PFKFB2 | alanine | Amino Acid | Alanine, Aspartate | 0.01 | 3.31E-07 |
| cg00683922 | PFKFB2 | alanine | Amino Acid | Alanine, Aspartate | 0.01 | 4.54E-07 |
| cg00683922 | PFKFB2 | erythronate* | Carbohydrate | Aminosugar | 0.01 | 2.87E-06 |
| cg00683922 | PFKFB2 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 7.71E-07 |
| cg00683922 | PFKFB2 | X—14,056 | Unnamed | Unnamed | 0.01 | 1.00E-05 |
| cg06291107 | BLCAP | mannonate* | Xenobiotics | Food Component/Plant | 0.01 | 3.08E-07 |
| cg06291107 | BLCAP | glucose | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | 0.01 | 5.76E-07 |
| cg06291107 | BLCAP | ribitol | Carbohydrate | Pentose | 0.01 | 6.12E-07 |
| cg06291107 | BLCAP | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 2.21E-07 |
| cg06291107 | BLCAP | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 8.49E-07 |
| cg01676795 | POR | 1,5-anhydroglucitol (1,5-AG) | Carbohydrate | Glycolysis, Gluconeogenesis, Pyruvate | -0.01 | 2.25E-07 |
| cg01676795 | POR | glycosyl ceramide (d18:2/24:1, d18:1/24:2)* | Lipid | Hexosylceramides (HCER) | -0.01 | 8.92E-06 |
| cg01676795 | POR | methylsuccinoylcarnitine | Amino Acid | Leucine, Isoleucine, Valine | 0.01 | 3.89E-06 |
| cg00092123 | KIAA1211L | mannonate* | Xenobiotics | Food Component/Plant | 0.01 | 4.37E-07 |
| cg09029192 | TNRC6C | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 7.23E-07 |
| cg09029192 | TNRC6C | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 2.36E-06 |
| cg13547913 | OCIAD1 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 8.90E-07 |
| cg13547913 | OCIAD1 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 1.51E-06 |
| cg18939666 | PEF1 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 9.27E-07 |
| cg18939666 | PEF1 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 3.02E-06 |
| cg18939666 | PEF1 | mannonate* | Xenobiotics | Food Component/Plant | 0.01 | 8.02E-06 |
| cg10167677 | THBS4 | mannonate* | Xenobiotics | Food Component/Plant | 0.01 | 1.06E-06 |
| cg10167677 | THBS4 | methylsuccinoylcarnitine | Amino Acid | Leucine, Isoleucine, Valine | 0.01 | 3.62E-06 |
| cg12350057 | PPP1R3E | erythronate* | Carbohydrate | Aminosugar | 0.01 | 1.14E-06 |
| cg00994936 | DAZAP1 | mannonate* | Xenobiotics | Food Component/Plant | 0.01 | 1.72E-06 |
| cg04326337 | RPRD1B | ribitol | Carbohydrate | Pentose | 0.01 | 1.73E-06 |
| cg06721411 | DQX1 | ribitol | Carbohydrate | Pentose | 0.01 | 2.10E-06 |
| cg06721411 | DQX1 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 4.59E-06 |
| cg06721411 | DQX1 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 7.90E-06 |
| cg27305772 | MUS81 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 2.32E-06 |
| cg09879165 | CACNA2D2 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.00 | 3.24E-06 |
| cg15007470 | TCF3 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 6.22E-06 |
| cg19707375 | BAIAP2-AS1 | glycosyl ceramide (d18:2/24:1, d18:1/24:2)* | Lipid | Hexosylceramides (HCER) | -0.01 | 9.55E-06 |
| cg08088075 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 1.73E-07 | |
| cg09777883 | ribitol | Carbohydrate | Pentose | 0.01 | 2.19E-07 | |
| cg08088075 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 2.54E-07 | |
| cg09777883 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 1.20E-06 | |
| cg09777883 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 0.01 | 2.70E-06 | |
| cg22896572 | ribitol | Carbohydrate | Pentose | 0.01 | 5.38E-06 |
a indicates associations previously reported in other studies. *indicates compounds that have not been officially confirmed based on a standard, but Metabolon is confident in its identity