TABLE 2.

All parameters extracted to characterize bone morphology (Bouxsein et al., 2010; Dempster et al., 2013).

Parameter	Symbol	Unit	Calculation/Reference	Voxel-size
Total volume	TV	mm³	Total bone volume, comprising mineral and pore volumes	2.27 µm
				640 nm
Mineral volume	BV	mm³		2.27 µm
				640 nm
Lacunar volume	LcV	µm³		2.27 µm
				640 nm
Lacunar porosity	LcV/BV	%	LcV/BV*100	2.27 µm
				640 nm
Lacunar density	NLc/BV	1/mm3		2.27 µm
				640 nm
Mineral distance (50%)	Ldist,min50	µm	Distance maps, histogram and cumulative summation	2.27 µm
				640 nm
Mineral distance (95%)	Ldist,min95	µm	Distance maps, histogram and cumulative summation	2.27 µm
				640 nm
Vessel distance (50%)	Ldist, vessel50	µm	Distance maps, histogram and cumulative summation	2.27 µm
				640 nm
Vessel distance (95%)	Ldist, vessel95	µm	Distance maps, histogram and cumulative summation (Dong et al., 2014)	2.27 µm
				640 nm
Mean value of lacunar volume	Ṽlac	µm3		2.27 µm
				640 nm
Standard deviation of lacunar volume	σlac	µm3		2.27 µm
				640 nm
Blood vessel volume	VV	µm³		2.27 µm
				640 nm
Vessel porosity	VV/BV	%	Vv/BV*100	2.27 µm
				640 nm
Level of alignment	LOA	-	Product of the variance of theta sΘ and the variance of phi sΦ (LOA = sΦ $\cdot$ sΘ)	2.27 µm
Angle Phi	Φ	°	Angle between a segment and the z–axis. Phi = 0° if the segment is parallel to a bone´s long axis	2.27 µm
Angle Theta	Θ	°	Projected angle between a segment and the x–axis. The segment is parallel to a bone’s surface if theta = 0°	2.27 µm
Ratio EV mean	EV mean	-	Mean of the ratios of the eigenvectors of the permeability tensor [(E2/E1) + (E3/E1)]/2	640 nm
PrincipalAxis Length ratio L1/L3	L1/L3	-	Ratio of the longest and shortest axes of the osteocyte lacunae	640 nm
Principal Axis Length ratio L1/L2	L1/L2	-	Ratio of the longest and second-longest axes of the osteocyte lacunae L1/L2	640 nm
Principal Axis Length ratio L2/L3	L2/L3	-	Ratio of the second-longest and shortest axes of the osteocyte lacunae L2/L3	640 nm