Table 2.
Platelet reactivity and prevalence of HPR according to DM and DM severity (total n = 11,714)
| Non-DM (N = 7,657) |
DM (N = 4,057) |
P-value | |||
|---|---|---|---|---|---|
| PRU (n = 11,714) | 213.6 ± 79.1 | 225.7 ± 77.5 | < 0.001 | ||
| HPR to ADP | 32.0% | 38.1% | < 0.001 | ||
| ARU (n = 7,162) | 442.1 ± 67.7 | 448.2 ± 72.3 | < 0.001 | ||
| HPR to arachidonic acid | 51.6% | 53.7% | 0.090 | ||
|
Non-DM (N = 7,657) |
DM without insulin (N = 3,787) |
DM on insulin (N = 270) |
P -value | ||
| PRU (n = 11,714) | 213.6 ± 79.1 | 225.3 ± 77.8 | 230.7 ± 73.2 | < 0.001 | |
| HPR to ADP | 32.0% | 37.7% | 44.0% | 0.001 | |
| ARU (n = 7,162) | 442.1 ± 67.7 | 446.7 ± 72.2 | 462.7 ± 74.0 | < 0.001 | |
| HPR to arachidonic acid | 51.6% | 52.8% | 63.8% | 0.002 | |
|
HbA1c < 6.5 (N = 2,541) |
6.5 ≤ HbA1c ≤ 8.5 (N = 1,192) |
HbA1c > 8.5 (N = 362) |
P -value | ||
| PRU (n = 4,095) | 216.1 ± 82.2 | 226.8 ± 81.6 | 229.4 ± 81.4 | < 0.001 | |
| HPR to ADP | 34.6% | 40.2% | 40.3% | 0.001 | |
| ARU (n = 1,115) | 436.4 ± 67.1 | 439.5 ± 70.6 | 449.7 ± 72.4 | 0.187 | |
| HPR to arachidonic acid | 45.9% | 47.1% | 54.0% | 0.314 | |
Continuous variables were expressed in mean ± SD.
‘HPR to ADP’ indicates ‘≥ 252 PRU’ and ‘HPR to arachidonic acid (AA)’ indicates ‘≥ 414 ARU’.
AA: arachidonic acid; ADP: adenosine diphosphate; ARU: aspirin reaction unit; DM: diabetes mellitus; HbA1c: hemoglobin A1c; HPR: high platelet reactivity; PRU: P2Y12 reaction unit