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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

4. Overview of included studies (PICO) ‐ Cardiovascular (vascular).

Study details Population (surgery type) CS detail Intervention detail Control detail Outcomes reported (time point)
Clagett 1999
RCT 
Registration: N/A 
Country: USA 
N = 100 Vascular (aortic surgery: abdominal aortic aneurysm, aortofemoral bypass) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 10 g/dL intraoperative; Hb < 8 g/dL postoperative; Hb < 10 g/dL cardiac 
System: Haemonetics Cell Saver (Haemonetics Corp, Braintree, Mass), or Cell Saver 3 Plus device or Cell Saver 5 device Intraoperative autotransfusion (IAT)
N = 50 Control
N = 50

  • Transfusions (intraoperative and postoperative)

  • Volume (intraoperative and postoperative)

  • Blood loss (intraoperative and postoperative)

  • Mortality (NR)

  • Wound complication (NR)

  • VTE/thrombosis (NR)

  • DVT (NR)

  • PE (NR)

  • MI (NR)

  • CVA/stroke (NR)

  • Hospital LOS
Davies 1987
RCT 
Registration: N/A 
Country: Australia 
N = 50 Vascular (abdominal aortic aneurysm or aortofemoral graft) Timing of collection: intraoperative 
Washing: unwashed 
Transfusion threshold: Hct < 30% 
System: Sorenson system (Sorensen Research Co, Salt Lake City, Utah, USA) Group A: autotransfusion (intra‐ and postoperative cell salvage)
N = 25 Group H: homologous transfusion without intraoperative salvage
N = 25

  • Volume (intraoperative and postoperative)

  • Blood loss (intraoperative)

  • Mortality (35 days)

  • Re‐operation (NR)
Kelley‐Patteson 1993
RCT 
Registration: N/A 
Country: USA 
N = 36 Vascular (aorto‐bifemoral bypass) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL 
System: Cell Saver Autotransfusion Device (Haemonetics Corp., Braintree, Mass.) AFB/CS
N = 18 AFB/no CS
N = 18

  • Transfusions (intraoperative only)

  • Volume (4 days)

  • Blood loss (NR)

  • Mortality (in‐hospital)

  • MI (NR)

  • Hospital LOS (NA)
Mercer 2004
RCT 
Registration: N/A 
Country: UK 
N = 81 Vascular (abdominal aortic aneurysm) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL 
System: Haemonetics Cell‐saver autologous blood recovery system (Haemonetics UK, Leeds, UK). Intraoperative autotransfusion (IAT)
N = 40 Homologous blood transfusion (HBT)
N = 41

  • Transfusions (intraoperative and postoperative)

  • Volume (NA)

  • Blood loss (NA)

  • Mortality (37 days postoperative)

  • Hospital LOS (NA)
Spark 1997
RCT 
Registration: N/A 
Country: UK 
N = 50 Vascular ‐ Abdominal Aortic Aneurysm Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hct < 25% 
System: COBE Baylor rapid autologous transfusion system (COBE laboratories Inc. Lakewood, Colorado, USA) Autologous blood
N = 23 Homologous blood
N = 27

  • Transfusions (until discharge)

  • Volume (NA)

  • Blood loss (NA)

  • Mortality (in‐hospital)

  • Re‐operation (in‐hospital)

  • Infection (in‐hospital)

  • Hospital LOS (NA)
Thompson 1990
RCT 
Registration: N/A 
Country: UK 
N = 67 Vascular ‐ Abdominal Aortic Aneurysm Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 10 g/dL + Hct < 30% 
System: Haemolite® device (Haemonetics, Leeds, UK) Cell Saver
N = 33 Controls
N = 34

  • Volume (NA)

  • Mortality (30 days)

  • Infection (NR)

  • MI (6 weeks)

  • Hospital LOS (NA)

ANH: acute normovolemic haemodilution; AT: autotransfusion; CABG: cardiopulmonary bypass graft; CS: cell salvage; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; Hct: haematocrit; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MI: myocardial infarction; N: planned recruitment (as reported by the study); NA: not analysable; NR: not reported; PE: pulmonary embolism; PJI: prosthetic joint infection; RAP: retrograde autologous prime; RCT: randomised controlled trial; VTE: venous thromboembolism

"Registration: N/A" means 'not applicable' as the study was published before 2010
"Volume" refers to mean transfusion volume
"Transfusions" refers to number of people receiving an allogeneic transfusion