Skip to main content
. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

5. Overview of included studies (PICO) ‐ Cardiovascular (no bypass).

Study details Population (surgery type) CS detail Intervention detail Control detail Outcomes reported (time point)
Damgaard 2006
RCT 
Registration: N/A 
Country: Denmark 
N = 60 Cardiothoracic (CABG) (off CPB) Timing of collection: postoperative 
Washing: unwashed 
Transfusion threshold: Hb < 6 mmol/L or Hct < 30% 
System: NR Cell saver
N = 30 Control: suction blood discharged
N = 30

  • Transfusions (24 hours)

  • Volume (NA)

  • Blood loss (NA)

  • Mortality (31 days)

  • Re‐operation (NR)

  • Wound complication (NR)

  • MI (NR)

  • CVA/stroke (NR)

  • Hospital LOS (NA)
Goel 2007
RCT 
Registration: N/A 
Country: India 
N = 49 Cardiothoracic (CABG) (off CPB) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 9 g/dL 
System: Dideco, Mirandola, Italy Group C: cell saver
N = 24 Group N: non‐cell saver
N = 25

  • Transfusions (intraoperative and in recovery room)

  • Volume (intraoperative and in recovery room)

  • Blood loss (postoperative only)

  • Mortality (5 days)

  • Re‐operation (in‐hospital)

  • Infection (in‐hospital)

  • Wound complication (in‐hospital)
Murphy 2005
RCT 
Registration: N/A 
Country: UK 
N = 61 Cardiothoracic (CABG) (off CPB) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL or Hct < 23% 
System: Dideco Compact autotransfuser device (Dideco, Gloucester, United Kingdom) Autotransfusion
N = 30 Control
N = 31

  • Transfusions (intraoperative and postoperative)

  • Volume (intraoperative and postoperative)

  • Mortality (in‐hospital)

  • Infection (NR)

  • Wound complication (NR)

  • MI (one month)

  • CVA/stroke (NR)

  • Hospital LOS (NA)
Niranjan 2006 ‐ SUBGROUP off‐CPB
RCT 
Registration: N/A 
Country: UK 
N = 40 Cardiovascular (CABG) (off CPB) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL 
System: Dideco Electa autotransfuser device (Dideco, Gloucester, United Kingdom) Group C (Off‐CPB with CSBT) 
N = 20 Group D (Off‐CPB without CSBT)
N = 20

  • Volume (24 hours)

  • Blood loss (24 hours)

  • Mortality (in‐hospital)

  • CVA/stroke (in‐hospital)

  • Hospital LOS
Zhao 1996
RCT 
Registration: N/A 
Country: China 
N = 42 Cardiothoracic (CABG, valve) Timing of collection: postoperative 
Washing: unwashed 
Transfusion threshold: No protocol 
System: simple recycling drainage system (Alium2050, USA) Group 1: autotransfusion of shed mediastinal blood (ATS)
N = 22 Group 2: non ATS (banked blood only)
N = 20

  • Volume (48 hours)

  • Blood loss (24 hours)
Zhao 2017
RCT 
Registration: No trial registration 
Country: China 
N = 120 Cardiothoracic (CABG) (off CPB) Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL 
System: Dideco Electa blood cell separator (Sorin Group, Italy) Experimental Group
N = 60 Control Group
N = 60

  • Volume (NR)

  • Hospital LOS

ANH: acute normovolemic haemodilution; AT: autotransfusion; CABG: cardiopulmonary bypass graft; CS: cell salvage; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; Hct: haematocrit; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MI: myocardial infarction; N: planned recruitment (as reported by the study); NA: not analysable; NR: not reported; PE: pulmonary embolism; PJI: prosthetic joint infection; RAP: retrograde autologous prime; RCT: randomised controlled trial; VTE: venous thromboembolism

"Registration: N/A" means 'not applicable' as the study was published before 2010
"Volume" refers to mean transfusion volume
"Transfusions" refers to number of people receiving an allogeneic transfusion