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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

10. Overview of included studies (PICO) ‐ Orthopaedic (spinal).

Study details Population (surgery type) CS detail Intervention detail Control detail Outcomes reported (time point)
Djurasovic 2018
RCT 
Registration: Prospective 
Country: USA 
N = 115 Orthopaedic (spinal) ‐ 2‐3 level decompression or fusion Timing of collection: intraoperative 
Washing: NR 
Transfusion threshold: Hb < 8 g/dL 
System: NR CS (Cell Saver)
N = 58 NCS (No Cell Saver)
N = 57

  • Transfusions (7 days)

  • Volume (7 days)

  • Blood loss (intraoperative)
Feiner 2015
RCT 
Registration: No trial registration 
Country: USA 
N = 77 Orthopaedic (spine) ‐ major spinal surgery Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: No protocol 
System: Fresnius‐Kabi Continuous AutoTransfusion System (C.A.T.S), Germany Group 1: cell salvage
N = 29 Group 2: Washed stored allogeneic transfusion; group 3: Unwashed stored allogeneic
N = 48 None reported
NCT 01251042 (#1794)
RCT 
Registration: Retrospective (2 months) 
Country: Denmark 
N = 49 Orthopaedic (any spinal surgery) Timing of collection: intraoperative 
Washing: unwashed 
Transfusion threshold: No protocol 
System: Sangvia® Blood Salvage System Sangvia and retransfusion
N = 26 Sangvia and no retransfusion
N = 23

  • Transfusions (7 days)

  • Blood loss (NA)

  • Wound complication (7 days)
Nemani 2019
RCT 
Registration: No trial registration 
Country: USA 
N = 63 Orthopaedic (spine) ‐ correction of deformity Timing of collection: postoperative 
Washing: washed 
Transfusion threshold: Hb < 8 g/dL 
System: OrthoPAT (Haemonetics) Group 1: OrthoPAT
N = 30 Group 2: Constavac, Stryker (standard subfascial closed suction drain)
N = 33

  • Transfusions (NA)

  • Volume (24 hours)

  • Blood loss (NR)

  • Infection (3 months)

  • PE (3 months)
Riou 1994
RCT 
Registration: N/A 
Country: France 
N = 50 Orthopaedic (any spinal surgery) Timing of collection: postoperative 
Washing: unwashed 
Transfusion threshold: Hct < 25% 
System: Solcotrans Orthopedic Plus system (Solco Basle Ltd, Bucks, UK) Solcotrans group
N = 25 Control group
N = 25

  • Transfusions (24 hours)
Savvidou 2009
RCT 
Registration: N/A 
Country: Greece 
N = 50 Orthopaedic (spine) ‐ lumbar fusion Timing of collection: intraoperative 
Washing: washed 
Transfusion threshold: Hb < 7 g/dL, Hct < 21% 
System: Dideco Electa Cell Saver (Sorin Group, Modena, Italy) Group A (perioperative cell saving technique)
N = 25 Group B (control)
N = 25

  • Volume (NR)

  • Blood loss (NR)

ANH: acute normovolemic haemodilution; AT: autotransfusion; CABG: cardiopulmonary bypass graft; CS: cell salvage; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; Hct: haematocrit; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MI: myocardial infarction; N: planned recruitment (as reported by the study); NA: not analysable; NR: not reported; PE: pulmonary embolism; PJI: prosthetic joint infection; RAP: retrograde autologous prime; RCT: randomised controlled trial; VTE: venous thromboembolism

"Registration: N/A" means 'not applicable' as the study was published before 2010
"Volume" refers to mean transfusion volume
"Transfusions" refers to number of people receiving an allogeneic transfusion