16. Overview of results: Cancer.

Outcome	Total [95% CI]	Subgroup: blood salvage (collection time)			Subgroup: transfusion threshold
		Intraoperative	Postoperative	Both	No transfusion threshold	Liberal threshold (Hb > 80 g/L)	Restrictive threshold (Hb < / = 80 g/L)
Risk of transfusion
Volume transfused (PPR)
Volume transfused (PPT)
All‐cause mortality	RR 0.56 (0.11, 2.80) 2 RCTs, N = 79 ⨁◯◯◯	RR 0.56 (0.11, 2.80) 2 RCTs, N = 79 ⨁◯◯◯			RR 0.56 (0.11, 2.80) 2 RCTs, N = 79 ⨁◯◯◯
Blood loss	MD 155.0 (‐253.39, 563.39) 1 RCT, N = 24 ⨁◯◯◯	MD 155.0 (‐253.39, 563.39) 1 RCT, N = 24 ⨁◯◯◯			MD 155.0 (‐253.39, 563.39) 1 RCT, N = 24 ⨁◯◯◯
Re‐operation
Infection	RR 0.77 (0.40, 1.50) 1 RCT, N = 55 ⨁◯◯◯	RR 0.77 (0.40, 1.50) 1 RCT, N = 55 ⨁◯◯◯			RR 0.77 (0.40, 1.50) 1 RCT, N = 55 ⨁◯◯◯
Wound complication
VTE/thrombosis
DVT	RR 0.50 (0.05, 4.81) 1 RCT, N = 24 ⨁◯◯◯	RR 0.50 (0.05, 4.81) 1 RCT, N = 24 ⨁◯◯◯			RR 0.50 (0.05, 4.81) 1 RCT, N = 24 ⨁◯◯◯
PE
MACE
MI
CVA/stroke
Hospital LOS

Bolded data highlights where there was a clear intervention effect.

"Volume" refers to mean transfusion volume; "transfusions" refers to number of people receiving an allogeneic transfusion

CI: confidence interval; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MD: mean difference; MI: myocardial infarction; N: number of people analysed; PE: pulmonary embolism; PJI: prosthetic joint infection; POR: Peto odds ratio; PPR: per person randomised; PPT: per person transfused; RCT: randomised controlled trial; RD: risk difference; RR: risk ratio; VTE: venous thromboembolism

⨁◯◯◯ = Very low certainty; ⨁⨁◯◯ = Low certainty; ⨁⨁⨁◯ = Moderate certainty; ⨁⨁⨁⨁ = High certainty