17. Overview of results: Cardiovascular (vascular).
| Outcome |
Total [95% CI] |
Subgroup: blood salvage (collection time) | Subgroup: transfusion threshold | ||||
| Intraoperative | Postoperative | Both | No transfusion threshold | Liberal threshold (Hb > 80 g/L) | Restrictive threshold (Hb ≦ 80 g/L) | ||
| Risk of transfusion | RR 0.61 [0.32, 1.15] 4 RCTs, N = 266 ⨁◯◯◯ |
RR 0.61 [0.32, 1.15] 4 RCTs, N = 266 ⨁◯◯◯ |
RR 0.39 [0.05, 3.20] 2 RCTs, N = 149 ⨁◯◯◯ |
RR 0.72 [0.51, 1.00] 2 RCTs, N = 117 ⨁◯◯◯ |
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| Volume transfused (PPR) | MD 0.03 [‐0.32, 0.37] 3 RCTs, N = 186 ⨁⨁◯◯ |
MD 0.03 [‐0.32, 0.37] 3 RCTs, N = 186 ⨁⨁◯◯ |
MD ‐0.32 [‐1.10, 0.47] 2 RCTs, N = 150 ⨁⨁⨁◯ |
MD 0.11 [‐0.28, 0.50] 1 RCT, N = 36 ⨁◯◯◯ |
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| Volume transfused (PPT) | MD 0.05 [‐0.64, 0.74] 2 RCTs, N = 74 ⨁⨁◯◯ |
MD 0.05 [‐0.64, 0.74] 2 RCTs, N = 74 ⨁⨁◯◯ |
MD ‐0.01 [‐0.86, 0.84] 1 RCT, N = 69 ⨁⨁⨁◯ |
MD 0.17 [‐1.01, 1.35] 1 RCT, N = 5 ⨁◯◯◯ |
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| All‐cause mortality | POR 1.19 [0.39, 3.65] 6 RCTs, N = 384 ⨁◯◯◯ |
POR 1.19 [0.39, 3.65] 6 RCTs, N = 384 ⨁◯◯◯ |
POR 1.23 [0.36, 4.16] 4 RCTs, N = 267 ⨁◯◯◯ |
POR 1.03 [0.06, 16.69] 2 RCTs, N = 117 ⨁◯◯◯ |
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| Blood loss | MD 106.19 [‐117.45, 329.83] 3 RCTs, N = 186 ⨁⨁◯◯ |
MD 106.19 [‐117.45, 329.83] 3 RCTs, N = 186 ⨁⨁◯◯ |
MD 2.48 [‐330.84, 335.80] 2 RCTs, N = 150 ⨁⨁◯◯ |
MD 191.11 [‐110.50, 492.72] 1 RCT, N = 36 ⨁⨁◯◯ |
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| Re‐operation | POR 1.08 [0.07, 17.40] 2 RCTs, N = 100 ⨁◯◯◯ |
POR 1.08 [0.07, 17.40] 2 RCTs, N = 100 ⨁◯◯◯ |
POR 1.08 [0.07, 17.40] 2 RCTs, N = 100 ⨁◯◯◯ |
||||
| Infection | RR 0.23 [0.03, 1.98] 2 RCTs, N = 117 ⨁◯◯◯ |
RR 0.23 [0.03, 1.98] 2 RCTs, N = 117 ⨁◯◯◯ |
RR 0.23 [0.03, 1.98] 2 RCTs, N = 117 ⨁◯◯◯ |
||||
| Wound complication | RR 1.00 [0.21, 4.72] 1 RCT, N = 100 ⨁◯◯◯ |
RR 1.00 [0.21, 4.72] 1 RCT, N = 100 ⨁◯◯◯ |
RR 1.00 [0.21, 4.72] 1 RCT, N = 100 ⨁◯◯◯ |
||||
| VTE/thrombosis | RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
||||
| DVT | RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
||||
| PE | RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
RD 0.00 [‐0.04, 0.04] 1 RCT, N = 100 ⨁◯◯◯ |
||||
| MACE | |||||||
| MI | POR 0.76 [0.17, 3.41] 3 RCTs, N = 203 ⨁◯◯◯ |
POR 0.76 [0.17, 3.41] 3 RCTs, N = 203 ⨁◯◯◯ |
POR 1.02 [0.20, 5.20] 2 RCTs, N = 167 ⨁◯◯◯ |
POR 0.14 [0.00, 6.82] 1 RCT, N = 36 ⨁◯◯◯ |
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| CVA/stroke | POR 0.14 [0.00, 6.82] 1 RCT, N = 100 ⨁◯◯◯ |
POR 0.14 [0.00, 6.82] 1 RCT, N = 100 ⨁◯◯◯ |
POR 0.14 [0.00, 6.82] 1 RCT, N = 100 ⨁◯◯◯ |
||||
| Hospital LOS | MD ‐0.50 [‐2.46, 1.46] 1 RCT, N = 100 ⨁⨁◯◯ |
MD ‐0.50 [‐2.46, 1.46] 1 RCT, N = 100 ⨁⨁◯◯ |
MD ‐0.50 [‐2.46, 1.46] 1 RCT, N = 100 ⨁⨁◯◯ |
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Bolded data highlights where there was close to an intervention effect (touched the line of no effect, so not entirely clear)
"Volume" refers to mean transfusion volume; "transfusions" refers to number of people receiving an allogeneic transfusion
CI: confidence interval; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MD: mean difference; MI: myocardial infarction; N: number of people analysed; PE: pulmonary embolism; PJI: prosthetic joint infection; POR: Peto odds ratio; PPR: per person randomised; PPT: per person transfused; RCT: randomised controlled trial; RD: risk difference; RR: risk ratio; VTE: venous thromboembolism
⨁◯◯◯ = Very low certainty; ⨁⨁◯◯ = Low certainty; ⨁⨁⨁◯ = Moderate certainty; ⨁⨁⨁⨁ = High certainty