18. Overview of results: Cardiovascular (no bypass).
| Outcome |
Total [95% CI] |
Subgroup: blood salvage (collection time) | Subgroup: transfusion threshold | ||||
| Intraoperative | Postoperative | Both | No transfusion threshold | Liberal threshold (Hb > 80 g/L) | Restrictive threshold (Hb ≦ 80 g/L) | ||
| Risk of transfusion |
RR 0.82 [0.69, 0.97] 3 RCTs, N = 169 ⨁⨁⨁◯ |
RR 0.83 [0.69, 1.00] * 2 RCTs, N = 110 ⨁⨁◯◯ |
RR 0.78 [0.53, 1.15] 1 RCT, N = 59 ⨁⨁◯◯ |
RR 0.83 [0.70, 0.98] 2 RCTs, N = 108 ⨁⨁⨁◯ |
RR 0.59 [0.19, 1.81] 1 RCT, N = 61 ⨁⨁◯◯ |
||
| Volume transfused (PPR) |
MD ‐0.90 [‐1.78, ‐0.01] 5 RCTs, N = 312 ⨁◯◯◯ |
MD ‐0.69 [‐1.64, 0.25] 4 RCTs, N = 270 ⨁◯◯◯ |
MD ‐2.30 [‐4.13, ‐0.47] 1 RCT, N = 42 ⨁◯◯◯ |
MD ‐2.30 [‐4.13, ‐0.47] 1 RCT, N = 42 ⨁◯◯◯ |
MD ‐0.86 [‐4.31, 2.59] 1 RCT, N = 49 ⨁◯◯◯ |
MD ‐0.68 [‐1.67, 0.31] 3 RCTs, N = 221 ⨁◯◯◯ |
|
| Volume transfused (PPT) | MD 0.13 [‐0.80, 1.07] 2 RCTs, N = 56 ⨁⨁◯◯ |
MD 0.13 [‐0.80, 1.07] 2 RCTs, N = 56 ⨁⨁◯◯ |
MD ‐0.55 [‐4.33, 3.23] 1 RCT, N = 45 ⨁⨁◯◯ |
MD 0.18 [‐0.79, 1.15] 1 RCT, N = 11 ⨁⨁◯◯ |
|||
| All‐cause mortality | POR 0.13 [0.01, 2.07] 4 RCTs, N = 209 ⨁◯◯◯ |
Not estimable (zero cases) 3 RCTs, N = 150 ⨁◯◯◯ |
POR 0.13 [0.01, 2.07] 1 RCT, N = 59 ⨁◯◯◯ |
POR 0.13 [0.01, 2.07] 2 RCTs, N = 108 ⨁◯◯◯ |
Not estimable (zero cases) 2 RCTs, N = 101 ⨁◯◯◯ |
||
| Blood loss | MD ‐62.55 [‐195.34, 70.24] 3 RCTs, N = 131 ⨁⨁◯◯ |
MD ‐23.31 [‐195.59, 148.96] 2 RCTs, N = 89 ⨁⨁⨁◯ |
MD ‐120.00 [‐328.45, 88.45] 1 RCT, N = 42 ⨁◯◯◯ |
MD ‐120.00 [‐328.45, 88.45] 1 RCT, N = 42 ⨁◯◯◯ |
MD 39.00 [‐411.23, 489.23] 1 RCT, N = 49 ⨁◯◯◯ |
MD ‐34.00 [‐220.47, 152.47] 1 RCT, N = 40 ⨁⨁⨁◯ |
|
| Re‐operation | RR 0.32 [0.04, 2.92] 2 RCTs N = 108 ⨁◯◯◯ |
Not estimable (zero cases) 1 RCT, N = 49 ⨁◯◯◯ |
RR 0.32 [0.04, 2.92] 1 RCT, N = 59 ⨁◯◯◯ |
RR 0.32 [0.04, 2.92] 1 RCTs, N = 108 ⨁◯◯◯ |
|||
| Infection | POR 2.06 [0.21, 20.61] 2 RCTs, N = 110 ⨁◯◯◯ |
POR 2.06 [0.21, 20.61] 2 RCTs, N = 110 ⨁◯◯◯ |
Not estimable (zero cases) 1 RCT, N = 49 ⨁◯◯◯ |
POR 2.06 [0.21, 20.61] 1 RCT, N = 61 ⨁◯◯◯ |
|||
| Wound complication | POR 1.00 [0.06, 15.98] 3 RCTs, N = 169 ⨁◯◯◯ |
POR 7.64 [0.15, 385.21] 2 RCTs, N = 110 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCT, N = 59 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCTs, N = 108 ⨁◯◯◯ |
POR 7.64 [0.15, 385.21] 1 RCT, N = 61 ⨁◯◯◯ |
||
| VTE/thrombosis | |||||||
| DVT | |||||||
| PE | |||||||
| MACE | |||||||
| MI | POR 1.98 [0.20, 19.32] 2 RCTs, N = 120 ⨁◯◯◯ |
POR 7.91 [0.48, 129.46] 1 RCT, N = 61 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCT, N = 59 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCT, n = 59 ⨁◯◯◯ |
POR 7.91 [0.48, 129.46] 1 RCT, N = 61 ⨁◯◯◯ |
||
| CVA/stroke | POR 0.98 [0.06, 15.72] 3 RCTs, N = 160 ⨁◯◯◯ |
POR 7.39 [0.15, 372.38] 2 RCTs, N = 101 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCT, N = 59 ⨁◯◯◯ |
POR 0.13 [0.00, 6.59] 1 RCT, N = 59 ⨁◯◯◯ |
POR 7.39 [0.15, 372.38] 2 RCTs, N = 101 ⨁◯◯◯ |
||
| Hospital LOS | MD ‐1.34 [‐3.62, 0.95] 2 RCTs, N = 160 ⨁◯◯◯ |
MD ‐1.34 [‐3.62, 0.95] 2 RCTs, N = 160 ⨁◯◯◯ |
MD ‐1.34 [‐3.62, 0.95] 2 RCTS, N = 160 ⨁◯◯◯ |
||||
Bolded data highlights where there was a clear intervention effect.
* neared an intervention effect (touched the line of no effect)
"Volume" refers to mean transfusion volume; "transfusions" refers to number of people receiving an allogeneic transfusion
CI: confidence interval; CVA: cerebrovascular accident; DVT: deep vein thrombosis; Hb: haemoglobin; LOS: hospital length of stay; MACE: major adverse cardiovascular events; MD: mean difference; MI: myocardial infarction; N: number of people analysed; PE: pulmonary embolism; PJI: prosthetic joint infection; POR: Peto odds ratio; PPR: per person randomised; PPT: per person transfused; RCT: randomised controlled trial; RD: risk difference; RR: risk ratio; VTE: venous thromboembolism
⨁◯◯◯ = Very low certainty; ⨁⨁◯◯ = Low certainty; ⨁⨁⨁◯ = Moderate certainty; ⨁⨁⨁⨁ = High certainty