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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

Comparison 5. Cardiovascular (vascular) (subgroup: transfusion threshold).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Transfusions 4 266 Risk Ratio (M‐H, Random, 95% CI) 0.61 [0.32, 1.15]
5.1.1 Restrictive (Hb ≦ 80 g/L) 2 117 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.51, 1.00]
5.1.2 Liberal (Hb > 80 g/L) 2 149 Risk Ratio (M‐H, Random, 95% CI) 0.39 [0.05, 3.20]
5.2 Volume of transfusion (units) (PPR) 3 186 Mean Difference (IV, Random, 95% CI) 0.03 [‐0.32, 0.37]
5.2.1 Restrictive (Hb ≦ 80 g/L) 1 36 Mean Difference (IV, Random, 95% CI) 0.11 [‐0.28, 0.50]
5.2.2 Liberal (Hb > 80 g/L) 2 150 Mean Difference (IV, Random, 95% CI) ‐0.32 [‐1.10, 0.47]
5.3 Volume of transfusion (units) (PPT) 2 74 Mean Difference (IV, Random, 95% CI) 0.05 [‐0.64, 0.74]
5.3.1 Restrictive (Hb ≦ 80 g/L) 1 5 Mean Difference (IV, Random, 95% CI) 0.17 [‐1.01, 1.35]
5.3.2 Liberal (Hb > 80 g/L) 1 69 Mean Difference (IV, Random, 95% CI) ‐0.01 [‐0.86, 0.84]
5.4 Mortality 6 384 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.19 [0.39, 3.65]
5.4.1 Restrictive (Hb ≦ 80 g/L) 2 117 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.03 [0.06, 16.69]
5.4.2 Liberal (Hb > 80 g/L) 4 267 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.23 [0.36, 4.16]
5.5 Blood loss (mL) 3 186 Mean Difference (IV, Random, 95% CI) 106.19 [‐117.45, 329.83]
5.5.1 Restrictive (Hb ≦ 80 g/L) 1 36 Mean Difference (IV, Random, 95% CI) 191.11 [‐110.50, 492.72]
5.5.2 Liberal (Hb > 80 g/L) 2 150 Mean Difference (IV, Random, 95% CI) 2.48 [‐330.84, 335.80]
5.6 Reoperation for bleeding 2 100 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.08 [0.07, 17.40]
5.6.1 Liberal (Hb > 80 g/L) 2 100 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.08 [0.07, 17.40]
5.7 Infection 2 117 Risk Ratio (M‐H, Random, 95% CI) 0.23 [0.03, 1.98]
5.7.1 Liberal (Hb > 80 g/L) 2 117 Risk Ratio (M‐H, Random, 95% CI) 0.23 [0.03, 1.98]
5.8 Wound complication 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
5.8.1 Liberal (Hb > 80 g/L) 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
5.9 Thrombosis (VTE) 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.9.1 Liberal (Hb > 80 g/L) 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.10 DVT 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.10.1 Liberal (Hb > 80 g/L) 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.11 PE 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.11.1 Liberal (Hb > 80 g/L) 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
5.12 MI 3 203 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.76 [0.17, 3.41]
5.12.1 Restrictive (Hb ≦ 80 g/L) 1 36 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.14 [0.00, 6.82]
5.12.2 Liberal (Hb > 80 g/L) 2 167 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.02 [0.20, 5.20]
5.13 CVA (stroke) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
5.13.1 Liberal (Hb > 80 g/L) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
5.14 Hospital LOS (days) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
5.14.1 Liberal (Hb > 80 g/L) 1   Mean Difference (IV, Random, 95% CI) Totals not selected