Comparison 6. Cardiovascular (no bypass) (subgroup: timing).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Transfusions	3	169	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.69, 0.97]
6.1.1 Intraoperative	2	110	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.69, 1.00]
6.1.2 Postoperative	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.53, 1.15]
6.2 Volume of transfusion (units) (PPR)	5	312	Mean Difference (IV, Random, 95% CI)	‐0.90 [‐1.78, ‐0.01]
6.2.1 Intraoperative	4	270	Mean Difference (IV, Random, 95% CI)	‐0.69 [‐1.64, 0.25]
6.2.2 Postoperative	1	42	Mean Difference (IV, Random, 95% CI)	‐2.30 [‐4.13, ‐0.47]
6.3 Volume of transfusion (units) (PPT)	2	56	Mean Difference (IV, Random, 95% CI)	0.13 [‐0.80, 1.07]
6.3.1 Intraoperative	2	56	Mean Difference (IV, Random, 95% CI)	0.13 [‐0.80, 1.07]
6.4 Mortality	4	209	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.01, 2.07]
6.4.1 Intraoperative	3	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	Not estimable
6.4.2 Postoperative	1	59	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.01, 2.07]
6.5 Blood loss (mL)	3	131	Mean Difference (IV, Random, 95% CI)	‐62.55 [‐195.34, 70.24]
6.5.1 Intraoperative	2	89	Mean Difference (IV, Random, 95% CI)	‐23.31 [‐195.59, 148.96]
6.5.2 Postoperative	1	42	Mean Difference (IV, Random, 95% CI)	‐120.00 [‐328.45, 88.45]
6.6 Reoperation for bleeding	2	108	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.04, 2.92]
6.6.1 Intraoperative	1	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
6.6.2 Postoperative	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.04, 2.92]
6.7 Infection	2	110	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.06 [0.21, 20.61]
6.7.1 Intraoperative	2	110	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.06 [0.21, 20.61]
6.8 Wound complication	3	169	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.00 [0.06, 15.98]
6.8.1 Intraoperative	2	110	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.64 [0.15, 385.21]
6.8.2 Postoperative	1	59	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.00, 6.59]
6.9 MI	2	120	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.98 [0.20, 19.32]
6.9.1 Intraoperative	1	61	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.91 [0.48, 129.46]
6.9.2 Postoperative	1	59	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.00, 6.59]
6.10 CVA (stroke)	3	160	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.98 [0.06, 15.72]
6.10.1 Intraoperative	2	101	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.39 [0.15, 372.38]
6.10.2 Postoperative	1	59	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.00, 6.59]
6.11 Hospital LOS (days)	2	160	Mean Difference (IV, Random, 95% CI)	‐1.34 [‐3.62, 0.95]
6.11.1 Intraoperative	2	160	Mean Difference (IV, Random, 95% CI)	‐1.34 [‐3.62, 0.95]