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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

Comparison 7. Cardiovascular (no bypass) (subgroup: transfusion threshold).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
7.1 Transfusions 3 169 Risk Ratio (M‐H, Random, 95% CI) 0.82 [0.69, 0.97]
7.1.1 Restrictive (Hb ≦ 80 g/L) 1 61 Risk Ratio (M‐H, Random, 95% CI) 0.59 [0.19, 1.81]
7.1.2 Liberal (Hb > 80 g/L) 2 108 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.70, 0.98]
7.2 Volume of transfusion (units) (PPR) 5 312 Mean Difference (IV, Random, 95% CI) ‐0.90 [‐1.78, ‐0.01]
7.2.1 Restrictive (Hb ≦ 80 g/L) 3 221 Mean Difference (IV, Random, 95% CI) ‐0.68 [‐1.67, 0.31]
7.2.2 Liberal (Hb > 80 g/L) 1 49 Mean Difference (IV, Random, 95% CI) ‐0.86 [‐4.31, 2.59]
7.2.3 No threshold/protocol reported 1 42 Mean Difference (IV, Random, 95% CI) ‐2.30 [‐4.13, ‐0.47]
7.3 Volume of transfusion (units) (PPT) 2 56 Mean Difference (IV, Random, 95% CI) 0.13 [‐0.80, 1.07]
7.3.1 Restrictive (Hb ≦ 80 g/L) 1 11 Mean Difference (IV, Random, 95% CI) 0.18 [‐0.79, 1.15]
7.3.2 Liberal (Hb > 80 g/L) 1 45 Mean Difference (IV, Random, 95% CI) ‐0.55 [‐4.33, 3.23]
7.4 Mortality 4 209 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.01, 2.07]
7.4.1 Restrictive (Hb ≦ 80 g/L) 2 0 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
7.4.2 Liberal (Hb > 80 g/L) 2 108 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.01, 2.07]
7.5 Blood loss (mL) 3 131 Mean Difference (IV, Random, 95% CI) ‐62.55 [‐195.34, 70.24]
7.5.1 Restrictive (Hb ≦ 80 g/L) 1 40 Mean Difference (IV, Random, 95% CI) ‐34.00 [‐220.47, 152.47]
7.5.2 Liberal (Hb > 80 g/L) 1 49 Mean Difference (IV, Random, 95% CI) 39.00 [‐411.23, 489.23]
7.5.3 No threshold/protocol reported 1 42 Mean Difference (IV, Random, 95% CI) ‐120.00 [‐328.45, 88.45]
7.6 Reoperation for bleeding 2 108 Risk Ratio (M‐H, Random, 95% CI) 0.32 [0.04, 2.92]
7.6.1 Liberal (Hb > 80 g/L) 2 108 Risk Ratio (M‐H, Random, 95% CI) 0.32 [0.04, 2.92]
7.7 Infection 2 110 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.06 [0.21, 20.61]
7.7.1 Restrictive (Hb ≦ 80 g/L) 1 61 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.06 [0.21, 20.61]
7.7.2 Liberal (Hb > 80 g/L) 1 0 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
7.8 Wound complication 3 169 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.00 [0.06, 15.98]
7.8.1 Restrictive (Hb ≦ 80 g/L) 1 61 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.64 [0.15, 385.21]
7.8.2 Liberal (Hb > 80 g/L) 2 108 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.00, 6.59]
7.9 MI 2 120 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.98 [0.20, 19.32]
7.9.1 Restrictive (Hb ≦ 80 g/L) 1 61 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.91 [0.48, 129.46]
7.9.2 Liberal (Hb > 80 g/L) 1 59 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.00, 6.59]
7.10 CVA (stroke) 3 160 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.98 [0.06, 15.72]
7.10.1 Restrictive (Hb ≦ 80 g/L) 2 101 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.39 [0.15, 372.38]
7.10.2 Liberal (Hb > 80 g/L) 1 59 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.00, 6.59]
7.11 Hospital LOS (days) 2 160 Mean Difference (IV, Random, 95% CI) ‐1.34 [‐3.62, 0.95]
7.11.1 Restrictive (Hb ≦ 80 g/L) 2 160 Mean Difference (IV, Random, 95% CI) ‐1.34 [‐3.62, 0.95]