Comparison 12. Orthopaedic (hip) (subgroup: timing).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
12.1 Transfusions	14	1641	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.38, 0.72]
12.1.1 Intraoperative	2	65	Risk Ratio (M‐H, Random, 95% CI)	0.60 [0.40, 0.89]
12.1.2 Postoperative	9	1168	Risk Ratio (M‐H, Random, 95% CI)	0.44 [0.26, 0.76]
12.1.3 Intra‐ and postoperative	4	408	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.41, 1.11]
12.2 Volume of transfusion (units) (PPR)	5	433	Mean Difference (IV, Random, 95% CI)	‐0.61 [‐1.04, ‐0.19]
12.2.1 Intraoperative	2	69	Mean Difference (IV, Random, 95% CI)	‐1.03 [‐1.61, ‐0.45]
12.2.2 Postoperative	2	160	Mean Difference (IV, Random, 95% CI)	‐0.78 [‐2.19, 0.63]
12.2.3 Intra‐ and postoperative	1	204	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.23, 0.03]
12.3 Volume of transfusion (units) (PPT)	4	63	Mean Difference (IV, Random, 95% CI)	‐1.74 [‐2.92, ‐0.55]
12.3.1 Intraoperative	1	16	Mean Difference (IV, Random, 95% CI)	‐2.04 [‐2.92, ‐1.16]
12.3.2 Postoperative	2	34	Mean Difference (IV, Random, 95% CI)	‐0.53 [‐2.98, 1.92]
12.3.3 Intra‐ and postoperative	1	0	Mean Difference (IV, Random, 95% CI)	Not estimable
12.4 Mortality	4	651	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.46 [0.06, 3.33]
12.4.1 Postoperative	2	317	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.19 [0.01, 3.20]
12.4.2 Intra‐ and postoperative	2	334	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.07 [0.07, 17.17]
12.5 Blood loss (mL)	10	1085	Mean Difference (IV, Random, 95% CI)	‐78.13 [‐162.74, 6.48]
12.5.1 Intraoperative	2	65	Mean Difference (IV, Random, 95% CI)	‐260.64 [‐1209.11, 687.83]
12.5.2 Postoperative	4	451	Mean Difference (IV, Random, 95% CI)	‐12.52 [‐27.17, 2.13]
12.5.3 Intra‐ and postoperative	4	569	Mean Difference (IV, Random, 95% CI)	‐111.32 [‐238.53, 15.89]
12.6 Reoperation for bleeding	1		Risk Difference (M‐H, Random, 95% CI)	Totals not selected
12.6.1 Postoperative	1		Risk Difference (M‐H, Random, 95% CI)	Totals not selected
12.7 Infection	4	549	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.72 [0.17, 2.98]
12.7.1 Postoperative	4	494	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.55 [0.12, 2.52]
12.7.2 Intra‐ and postoperative	1	55	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.81 [0.08, 283.10]
12.8 Wound complication	4	609	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.94 [0.36, 2.45]
12.8.1 Postoperative	3	338	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.18 [0.38, 3.65]
12.8.2 Intra‐ and postoperative	2	271	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.54 [0.09, 3.22]
12.9 Prosthetic joint infection (PJI)	5	806	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.31 [0.05, 1.78]
12.9.1 Postoperative	2	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	Not estimable
12.9.2 Intra‐ and postoperative	4	593	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.31 [0.05, 1.78]
12.10 Thrombosis (VTE)	2	196	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.45 [0.24, 8.72]
12.10.1 Postoperative	2	196	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.45 [0.24, 8.72]
12.11 DVT	3	343	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.05 [0.20, 5.60]
12.11.1 Intraoperative	1	39	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.66 [0.26, 10.58]
12.11.2 Postoperative	1	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	Not estimable
12.11.3 Intra‐ and postoperative	1	204	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.00, 6.82]
12.12 PE	2	316	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.00, 7.08]
12.12.1 Postoperative	1	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	Not estimable
12.12.2 Intra‐ and postoperative	1	216	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.00, 7.08]
12.13 CVA (stroke)	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
12.13.1 Intraoperative	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
12.14 Hospital LOS (days)	4	542	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.37, 0.52]
12.14.1 Postoperative	2	220	Mean Difference (IV, Random, 95% CI)	0.19 [‐0.79, 1.17]
12.14.2 Intra‐ and postoperative	2	322	Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.50, 0.47]