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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

Comparison 14. Orthopaedic (knee) (subgroup: timing).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
14.1 Transfusions 21 2214 Risk Ratio (M‐H, Random, 95% CI) 0.49 [0.37, 0.66]
14.1.1 Postoperative 20 1939 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.32, 0.63]
14.1.2 Intra‐ and postoperative 2 275 Risk Ratio (M‐H, Random, 95% CI) 0.82 [0.67, 1.01]
14.2 Volume of transfusion (units) (PPR) 5 563 Mean Difference (IV, Random, 95% CI) ‐0.87 [‐1.09, ‐0.64]
14.2.1 Postoperative 5 428 Mean Difference (IV, Random, 95% CI) ‐0.84 [‐1.13, ‐0.55]
14.2.2 Intra‐ and postoperative 1 135 Mean Difference (IV, Random, 95% CI) ‐0.93 [‐1.29, ‐0.57]
14.3 Volume of transfusion (units) (PPT) 3 221 Mean Difference (IV, Random, 95% CI) ‐0.54 [‐0.90, ‐0.19]
14.3.1 Postoperative 3 130 Mean Difference (IV, Random, 95% CI) ‐0.37 [‐0.81, 0.07]
14.3.2 Intra‐ and postoperative 1 91 Mean Difference (IV, Random, 95% CI) ‐0.89 [‐1.16, ‐0.62]
14.4 Blood loss (ml) 9 629 Mean Difference (IV, Random, 95% CI) ‐79.01 [‐170.27, 12.24]
14.4.1 Postoperative 9 629 Mean Difference (IV, Random, 95% CI) ‐79.01 [‐170.27, 12.24]
14.5 Reoperation for bleeding 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.5.1 Postoperative 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.6 Infection 5 730 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.74 [0.28, 1.94]
14.6.1 Postoperative 5 595 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.86 [0.29, 2.52]
14.6.2 Intra‐ and postoperative 1 135 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.43 [0.05, 3.57]
14.7 Wound complication 6 734 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.42 [0.61, 3.31]
14.7.1 Postoperative 6 734 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.42 [0.61, 3.31]
14.8 Prosthetic joint infection (PJI) 4 663 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.01, 0.01]
14.8.1 Postoperative 4 528 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.01, 0.01]
14.8.2 Intra‐ and postoperative 1 135 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.03, 0.03]
14.9 DVT 9 793 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.29 [0.56, 2.95]
14.9.1 Postoperative 9 793 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.29 [0.56, 2.95]
14.10 PE 6 574 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.51 [0.10, 2.52]
14.10.1 Postoperative 6 574 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.51 [0.10, 2.52]
14.11 MACE 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.11.1 Postoperative 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.12 MI 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
14.12.1 Postoperative 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
14.13 CVA (stroke) 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.13.1 Postoperative 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
14.14 Hospital LOS (days) 4 255 Mean Difference (IV, Random, 95% CI) ‐0.79 [‐2.30, 0.72]
14.14.1 Postoperative 4 255 Mean Difference (IV, Random, 95% CI) ‐0.79 [‐2.30, 0.72]