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. 2023 Sep 8;2023(9):CD001888. doi: 10.1002/14651858.CD001888.pub5

Comparison 18. Orthopaedic (mixed) (subgroup: timing).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
18.1 Transfusions 11 4011 Risk Ratio (M‐H, Random, 95% CI) 0.64 [0.45, 0.90]
18.1.1 Intraoperative 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.62 [0.38, 1.02]
18.1.2 Postoperative 7 1349 Risk Ratio (M‐H, Random, 95% CI) 0.60 [0.40, 0.90]
18.1.3 Intra‐ and postoperative 3 2622 Risk Ratio (M‐H, Random, 95% CI) 0.74 [0.34, 1.59]
18.2 Volume of transfusion (units) (PPR) 5 2687 Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.85, 0.08]
18.2.1 Intraoperative 1 40 Mean Difference (IV, Random, 95% CI) ‐0.68 [‐0.98, ‐0.38]
18.2.2 Postoperative 2 146 Mean Difference (IV, Random, 95% CI) ‐0.28 [‐1.27, 0.71]
18.2.3 Intra‐ and postoperative 2 2501 Mean Difference (IV, Random, 95% CI) ‐0.32 [‐1.16, 0.52]
18.3 Volume of transfusion (units) (PPT) 5 395 Mean Difference (IV, Random, 95% CI) ‐0.24 [‐0.73, 0.24]
18.3.1 Intraoperative 1 26 Mean Difference (IV, Random, 95% CI) ‐0.58 [‐0.72, ‐0.44]
18.3.2 Postoperative 2 65 Mean Difference (IV, Random, 95% CI) ‐0.02 [‐1.00, 0.97]
18.3.3 Intra‐ and postoperative 2 304 Mean Difference (IV, Random, 95% CI) ‐0.23 [‐1.03, 0.58]
18.4 Mortality 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
18.4.1 Postoperative 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
18.5 Blood loss (mL) 2 99 Mean Difference (IV, Random, 95% CI) ‐28.78 [‐97.43, 39.88]
18.5.1 Intraoperative 1 40 Mean Difference (IV, Random, 95% CI) ‐30.30 [‐100.75, 40.15]
18.5.2 Intra‐ and postoperative 1 59 Mean Difference (IV, Random, 95% CI) 0.00 [‐306.24, 306.24]
18.6 Infection 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
18.6.1 Postoperative 1   Risk Difference (M‐H, Random, 95% CI) Totals not selected
18.7 Wound complication 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
18.7.1 Postoperative 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
18.8 Prosthetic joint infection (PJI) 3 826 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.25 [0.44, 3.51]
18.8.1 Postoperative 3 826 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.25 [0.44, 3.51]
18.9 Thrombosis (VTE) 2 278 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.02, 0.02]
18.9.1 Postoperative 2 278 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.02, 0.02]
18.10 DVT 4 3295 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.41 [0.09, 1.92]
18.10.1 Postoperative 3 853 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.99 [0.09, 10.99]
18.10.2 Intra‐ and postoperative 1 2442 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.22 [0.03, 1.67]
18.11 PE 4 3295 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.86 [0.48, 7.27]
18.11.1 Postoperative 3 853 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.44 [0.18, 11.64]
18.11.2 Intra‐ and postoperative 1 2442 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.25 [0.37, 13.57]
18.12 MI 2 3017 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.62 [0.17, 2.22]
18.12.1 Postoperative 1 575 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.05 [0.00, 3.13]
18.12.2 Intra‐ and postoperative 1 2442 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.81 [0.21, 3.08]
18.13 Hospital LOS (days) 2 160 Mean Difference (IV, Random, 95% CI) ‐0.02 [‐1.94, 1.90]
18.13.1 Postoperative 2 160 Mean Difference (IV, Random, 95% CI) ‐0.02 [‐1.94, 1.90]