Type of surgery	All data RR (95% CI) (Analysis 1.1)	Sensitivity analysis: registration status (Analysis 1.2)	Sensitivity analysis: low ROB in domains of interest (Analysis 1.3)
All surgeries (aggregate analysis)	0.65 (0.59, 0.72) 82 RCTs N = 12,520	0.62 (0.55, 0.70) 58 RCTs N = 6353	0.74 (0.61, 0.89) 17 RCTs N = 6398
Cancer	No data for this outcome	No data for this outcome	No data for this outcome
Cardiovascular (vascular)	0.61 (0.32, 1.15) 4 RCTs N = 266	0.61 (0.32, 1.15) 4 RCTs N = 266	0.92 (0.70, 1.19) 1 RCT N = 100
Cardiovascular (no bypass)	0.82 (0.69, 0.97) 3 RCTs N = 169	0.82 (0.69, 0.97) 3 RCTs N = 169	0.59 (0.19, 1.81) 1 RCT N = 61
Cardiovascular (with bypass)	0.81 (0.73, 0.89) 25 RCTs N = 2676	0.79 (0.70, 0.89) 20 RCTs N = 1756	0.82 (0.70, 0.97) 5 RCTs N = 1344
Obstetrics	0.82 (0.38, 1.76) 1 RCT N = 1349	0.82 (0.38, 1.76) 1 RCT N = 1349	0.82 (0.38, 1.76) 1 RCT N = 1349
Orthopaedic (hip)	0.52 (0.38, 0.72) 14 RCTs N = 1641	0.47 (0.27, 0.80) 7 RCTs N = 585	0.36 (0.26, 0.51) 1 RCT N = 200
Orthopaedic (knee)	0.49 (0.37, 0.66) 21 RCTs N = 2214	0.40 (0.26, 0.60) 13 RCTs N = 1210	0.66 (0.29, 1.50) 4 RCTs N = 544
Orthopaedic (spinal)	0.44 (0.31, 0.63) 3 RCTs N = 194	0.54 (0.34, 0.85) 2 RCTs N = 145	0.50 (0.05, 5.17) 1 RCT N = 50
Orthopaedic (mixed)	0.64 (0.45, 0.90) 11 RCTs N = 4011	0.53 (0.39, 0.72) 8 RCTs N = 873	0.74 (0.35, 1.59) 3 RCTs N = 2750